|Dept:||Chemical Biological and Pharmaceutical Engineering|
Dr. Xiaoyang Xu comes to NJIT from MIT, where he was an NIH postdoctoral fellow advised by Institute Professor Robert Langer and co-mentored by Professor Omid Farokhzad (Harvard Medical School). He completed his Ph.D. in Material Chemistry at Northwestern University under the supervision of Prof. Chad Mirkin. His research focus is the development of novel biomaterials and nanotechnologies for a variety of medical applications including diagnosis, bioimaging, drug delivery, and regenerative medicine. He looks at both fundamental and applied questions in the cross-disciplinary fields of biomaterials and medicine in order to develop novel therapeutic methods for the treatment of cancer, obesity, and cardiovascular disease. His research has been published in high-impact journals such as the Proceedings of the National Academy of Sciences of the United States of America, the Journal of the American Chemical Society, Angewandte Chemie International Edition, ACS Nano, Nano Letters, Small and Advanced Materials.
- NIH Postdoctoral Fellow, Chemical Engineering, Koch Institute, Massachusetts Institute of Technology | Harvard Medical School (advisor: Prof. Robert Langer, co-mentor: Prof. Omid Farokhzad)
- Ph.D., Chemistry, International Institute for Nanotechnology, Northwestern University, Evanston (advisor: Chad Mirkin)
- B.S., Chemical Engineering, East China University of Science and Technology
Awards and Honors
AACR Scholar-in-Training Award 2013
Ruth L. Kirschstein National Research Service Awards (NRSA) 2011
Chinese Government Award for Outstanding Chinese Students Study Abroad 2010
Northwestern University Graduate School Travel Award 2007
Northwestern University Chemistry Department Fellowship 2004
Utilizing chemistry, materials science and engineering techniques, we explore the interface of biomaterials and medicine and address fundamental questions in the two cross-disciplinary fields.
One specific goal lies in developing multifunctional biomaterials for medical applications including therapeutic delivery and regenerative medicine. For example, we investigate the synergistic effects of combinatorial drug delivery for cancer treatment through the creation of nanocarrier plaforms which can simultaneously deliver therapeutics and small interfering RNA (siRNA).
In parallel, we are interested in developing synthetic biomaterials and processing techniques to fabricate hydrogels and scaffolds for use in drug delivery and tissue engineering. In particular we focus on biomaterials engineering to understand structure-function relationships and investigate the effects of biomaterials characteristics on therapeutics release, and cellular/tissue interactions.
Xiaoyang Xu, Yuan Xue; Xueqing Zhang; Omid C. Farokhzad; Robert S. Langer; Targeted nanoparticle compositions and methods of their use to treat obesity; filed in July 2013. U.S.S.N. 61/940,732.
Xueqing Zhang; Xiaoyang Xu; Nazila Kamaly; Mingming Ma; Robert S. Langer; Omid C. Farokhzad;Multimodel Nanoparticles for Targeted Drug Delivery and Imaging; filed in Oct 2012. U.S.S.N. 61/799,171.
Xiaoyang Xu, Omid C. Farokhzad; Robert S. Langer; Cationic PLGA-PEG based Nanoparticle Delivery System; U.S.S.N. 61/892,273.
Wei Wei, Xiaoyang Xu, Lidong Qin, Kan Xue, Jill Millstone, Chad A. Mirkin. Energy Transfer through Surface Plasmon Resonance Excitation on Multisegmented Nanowires, U.S. Patent Application Serial No. 204/157.46
Xiaoyang Xu, Fengwei Huo, Abigail K.R. Lytton-Jean; Nathaniel L. Rosi; Yuhuang Wang; Chad A.Mirkin; Asymmetric Functionalizated Nanoparticles And Methods Of Use, filed in July 2006, Northwestern University. (WO2008097328-A2; WO2008097328-A3)
Xiaoyang Xu; Min Su Han; Chad A. Mirkin; Real-Time Colorimetric Screening Inhibitors of Endonuclease with Gold Nanoparticle Substrat, U.S. Patent Application Serial No. 435/6.12.
Xiaoyang Xu; Xiaodong Chen; Daniel L. Weston; Michael J. Wiester; Adam B. Braunschweig; Chad A. Mirkin; Click Chemistry, Molecular Transport Junctions, And Colorimetric Detection Of Copper, U.S. Patent Application Serial No. 204/157.46 436/80
Peer Reviewed Journal Papers
Zhang, X.; Even-Or, O.; Xu, X.; Rosmalen, M.; Lim, L.; Gadde, S.; Farokhzad, O.; Fisher, E. A. “Nanoparticles Containing a Liver X Receptor Agonist Inhibit Inflammation and Atherosclerosis” Adv. Healthcare Mater.2014 (in press)
Wu, J.; Kamly, N.; Shi, J.; Zhao, L.; Xiao, Z.; Hollett, G.; John, R.; Ray. S.; Xu, X.; Zhang, X; Kantoff, P.; Farokhzad C. O. “Development of multinuclear polymeric nanoparticles as robust protein nanocarriers” Angew. Chem. Int. Ed. 2014 (in press)
Shi, J.; Xu, Y.; Xu, X.; Zhu, X.; Pridgen, E.; Votruba, A.; Zetter, B.; Farokhzad C. O. “Hybrid Lipid-Polymer Nanoparticles for Sustained siRNA Delivery and Gene Silencing”Nanomed Nanotech Biol Med 2014 (in press)
Bertrand, N.; Wu, J.; Xu, X.; Kamaly, N.; Farokhzad, C. O. “Cancer Nanotechnology: The impact of passive and active targeting in the era of modern cancer biology” Adv. Drug Deliv. Rev. 2014; 66, 2-25.
Xu, X; Xie, K; Zhang, X; Pridgen, E; Park, G; Lippard, S. J.; Langer, R. S.; Walker G. C.; Farokhzad C. O. “Enhancing Tumor Cell Response to Chemotherapy through Nanoparticle-Mediated Co-delivery of siRNA and Cisplatin Prodrug” Proc Natl Acad Sci USA. 2013;110(46), 18638-18643.
Xu, X*; Zhang, X*; Bertrand, N; Pridgen, E; Swami A; Farokhzad C. O. “Interactions of nanomaterials and biological systems: Implications to personalized nanomedicine” Adv. Drug Deliv. Rev.; 2012; 64(13), 1363-1384. (* equally contribute)
Cheng H; Byrska-Bishop M; Zhang T. C; Kastrup J. C; Hwang S. N; Tai K. A; Lee W. W; Xu X; Nahrendorf M; Langer S. R; Anderson G. D. “Stem cell membrane engineering for cell rolling using peptide conjugation and tuning of cell–selectin interaction kinetics” Biomaterials; 2012; 33(20), 5004-5012.
Xu, X.*; Zhang, X.*; Lam, R.; Giljohann, D.; Ho, D.; and Mirkin C. A. “A Strategy for Increasing Drug Solubility and Efficacy through Covalent Attachment to Polycalent DNA-Nanoparticle Conjugates.” ACS Nano, 2011, 5 (9), 6962–6970. (* equally contribute)
Zhang, X.; Lam, R.; Xu, X.; Kim, H.; and Ho. D. “Multimodal Nanodiamond Drug Delivery Carriers for Selective Targeting, Imaging and Enhanced Chemotherapeutic Efficacy” Adv. Mater. 2011; 23(41), 4770-4775.
Cutler, J. I.; Zheng, D.; Xu, X.; Jiyohann D. A.; Mirkin C. A. "Polyvalent Oligonucleotide Iron Oxide Nanoparticle "Click" Conjugates" Nano Lett.; 2010; 10 (4), 1477–1480.
Xu, X.; Deniel, W.; Wei, W.; Mirkin, C. A."Colorimetric Detection Cu2+using DNA/NanoparticleConjugates and Click Chemistry" Small; 2009;6 (5), 623-626.
Zhang, X; Chen, M; Lam, R;Xu, X; Ho, D; “Polymer-Functionalized Nanodiamond Platforms as Vehicles for Gene Delivery.” AcsNano. 2009; 3(9), 2609-2616.
Shimkunas, R; Robinson, E; Lam, R; Zhang, X;Xu, X; Ho, D. “Nanodiamond-Insulin Complexes as pH-Dependent Protein Delivery Vehicles.” Biomaterials. 2009; 30 (29), 5720-5728.
Xu, X. *; Song, Y. *; MacRenaris, K. W.; Zhang, X.; Mirkin, C. A.; Meade, T. J. "Multimodal Gadolinium-Enriched DNA Gold Nanoparticle Conjugates for CellularImaging" Angew. Chem. Int. Ed. 2009; 48(48),9143-9147. (* equally contribute)
Zhang, X; Tang, H; Hosh, I; Laporte, L. D; Qiu, H; Xu, X; Shea, L. D.; Ameer, G. A."Sustained Transgene Expression via Citric Acid-based Polyester Elastomers" Biomaterials; 2009; 30(13), 2632- 2641.
Wei, W; Li, S; Millstone, J. E; Banholzer, M; Chen, X; Xu, X; Schatz, G. C.; Mirkin, C. A. "SurprisinglyLong-Range Surface Enhanced Raman Scattering (SERS) on Au-Ni Multisegmented Nanowires" Angew. Chem. Int. Ed. 2009; 48, 4210-4212.
Xu, X.; Zhao, Z.; Qin, L.; Wei, W.; Levin, J. E.; Mirkin, C. A. "A Fluorescence Recovery Assay for the Detection of Protein-DNA binding" Anal.Chem. 2008; 80(14); 5616-5621.
Wei, W., Qin, L.; Xue, C.; Millstone, J. E.; Xu, X.; Li, S.; Schatz, G. C.; Mirkin, C. A."Energy Transfer through Surface Plasmon Resonance Excitation on Multisegmented Nanowires" Nano Lett.; 2008; 8 (10), 3446–3449.
Xu, X.; Han, M. S.; Mirkin, C. A. "A Gold-Nanoparticle-Based Real-Time Colorimetric Screening Method for Endonuclease Activity and Inhibition" Angew. Chem. Int. Ed. 2007; 46(19); 3468-3470. (Selected as "VIP paper")
Qin, L.; Banholzer, M. J.; Xu, X.; Huang, L.; Mirkin, C. A. "Rational Design and Synthesis of Catalytically Driven Nano Rotors" J. Am. Chem. Soc. 2007; 129(48); 14870-14871.
Xu, X.; Georganopoulou, D. G.; Hill, H. D.; Mirkin, C. A. "Homogeneous Detection of Nucleic Acids Based Upon the Light Scattering Properties of Silver-coated Nanoparticle Probes" Anal. Chem. 2007; 79(17); 6650-6654.
Xu, X.; Rosi, N. L.; Wang, Y.; Huo, F.; Mirkin, C. A. "Asymmetric Functionalization of Gold Nanoparticles with Oligonucleotides" J. Am. Chem. Soc. 2006; 128(29); 9286- 9287.