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Department of Chemical Biological and Pharmaceutical Engineering

Bilgili, Ecevit A.

Contact Info
Title: Assistant Professor
Email: ecevit.a.bilgili@njit.edu
Office: Tiernan Hall 382
Phone: 973-596-2998
Dept: Chemical, Biological & Pharmaceutical Engineering
Webpage: http://chemicaleng.njit.edu/people/bilgili.php

About Me

Ecevit Bilgili received his B.S. degree in chemical engineering from Bogazici University in Istanbul, Turkey in 1996 at the top of his class. He received his Ph.D. degree in chemical engineering from the Illinois Institute of Technology, Chicago in May 2001. The PhD work led to the Best PhD Thesis Award by the Particle Technology Forum of AIChE in 2004. The work, which was multi-disciplinary by nature, shed fundamental light on the mechano-chemical nature of a novel rubber recycling process. Between 2001 and late 2004, Dr. Bilgili worked as a post-doctoral research associate at the Particle Engineering Research Center, University of Florida. His research interests centered on the processing, characterization, and modeling of particulate unit operations and powders. The experimental and theoretical work focused on powder flow in shear testers, nanoparticle production via stirred media milling as well as population balance modeling of size reduction operations.

From early 2005 till August 2009, Dr. Bilgili worked as Senior and Principal Development Engineer within Pharmaceutical Commercialization Technology Department (formerly Pharmaceutical Development) at Merck & Co., Inc. As a technical leader, he played a major role in the development, filing, and commercialization of a recently approved diabetes drug. He led various technology and engineering science initiatives within Merck, and received a Special Achievement Award, Fluidized Bed Technology Mastery Award, and many Awards of Excellence. Before joining NJIT, Dr. Bilgili was developing a Dry Powder Inhaler formulation and serving as a technical consultant to multiple drug development programs.
 
Dr. Bilgili joined the Chemical, Biological, and Pharmaceutical Engineering Department in Fall 2009. He will continue to further his research on the production, engineering, and characterization of particulate materials and their application in a variety of industries including the pharmaceutical industry. Specifically, Dr. Bilgili is interested in nanoparticle production via various technologies such as nanomilling, solid dispersion preparation using spray drying and fluid bed granulation/coating as well as modeling of the aforementioned technologies.
 
Dr. Bilgili is a well-recognized member of the Particle Technology Community. He is one of the youngest elected Executive Committee Member of the Particle Technology Forum of AIChE. He has published 25 journal articles, more than 40 national/international presentations, 9 invited talks, and 2 U.S. patents. He serves as a referee to many journals, as a session chair in various national and international conferences, and as a member of AIChE and ACS. He was one of the organizers of the Topical Conference titled Pharmaceutical Engineering for the 21st Century at the AIChE Annual Meeting in 2007. He is the recipient of Who’s Who in Science and Engineering, Who’s Who of Emerging Leaders, and Professor Turgut Noyan Award among many others. He is happily married to Melike with daughter Melisa. 

Education

 

  • Ph.D.(May 2001), Chemical Engineering., Illinois Institute of Technology, Chicago, IL.
  • B.S.(June 1996), Chemical Engineering., Bogazici University, Istanbul, Turkey.
 

Honors and Awards

 

  • PCT & GPC Operations Technology Mastery Award, by Merck & Co., in recognition of the efforts towards developing the fluid bed granulation technology, 2009 
  • Marquis Who´s Who in Science and Engineering appeared in the 7th, 9th, and 10th Eds., 2003–2004, 2006–2007, and 2008–2009.
  • Award of Excellence, by Merck & Co., Inc. in recognition of significant contributions to a drug development program, 2008
  • Marquis Who´s Who of Emerging Leaders, appeared in the 1st Ed., 2006–2007
  • Award of Excellence, by Merck & Co., Inc. in recognition of significant contributions to an accelerated drug filing, 2006
  • Special Achievement Award, by Merck & Co., Inc. in recognition of personal dedication and technical contributions to a drug development program, 2005
  • Best Ph.D. Thesis in Particle Technology Award, by Particle Technology Forum of the American Institute of Chemical Engineers, 2004 
  • Marquis Who´s Who in America, appeared in the 56th, 57th, and 58th Editions, 2002, 2003, and 2004    
  • Certificate of The Highest Standards of Academic Achievement given by IIT, Chicago, 2001
  • Who´s Who Among Students in American Universities and Colleges, 1998–2001
  • The Professor Turgut Noyan Award given by the Chemical Engineering Department, Bogazici University, 1996

 


Courses I Teach

DOCT DISSERTATION & RES
DOCT DISSERTATION & RES

Research Interests

Professor Bilgili’s general research area is Particle Science and Engineering as applied to high-value-added product industries such as pharmaceuticals, diagnostic agents, nutraceuticals, agrochemicals, inks, etc. with a primary focus on pharmaceuticals and health sciences.

 

The specific problems/issues Prof. Bilgili would like to solve and address:
  • Poor water-solubility and inadequate bioavailability of more than 40% of the newly discovered drugs, which prevents or delays formulation development and commercialization
  •  Inability to prepare and stabilize sub100 nm drug particles in suspensions, which is a barrier to bioavailability enhancement and sterile filtration of drug nanoparticle suspensions
  • Excessive use of surfactants and sugars in nanoparticulate drug formulations
  • Lack of predictive tools/models for production of drug nanoparticles and their composites
  • Poor understanding of non-linear effects, mechanical multi-particle interactions, and empirical nature of kernels in population balance modeling
Professor Bilgili’s long-term research goals are to
  • Develop a fundamental understanding of the controlling mechanical/physico-chemical parameters and mechanisms by which drug nanoparticles, especially ones with sub-100 nm particles, can be produced.
  • Elucidate the dynamics and mechanisms by which active nanoparticles are recovered from solid dosage forms such as nanocomposite microparticles (NCMPs), strip films, and tablets during wet dispersion/dissolution in physiologically relevant fluids.
  • Develop a mechanistic understanding of the functional responses of active (drug) agent-carrying solid dosage forms via process–structure–property–performance interrelationships
  • Extend/apply the fundamental learning and research findings from the pharmaceuticals-centric (drug) research to other active agents like agrochemicals, biological agents, etc.
  • Develop mechanistic, particle-scale kernels for population balance models that allow for multi-scale modeling of particle formation processes and elucidation of the elusive non-linear effects

Recent Publications

Recent Peer Refereed Journal Papers (Lead author underlined)

1.    C. Ravikumar, M. Li, N.K.R.Yaragudi, A. Afolabi, R.N. Dave, E. Bilgili, “Sub-100 nm Drug Particle Suspensions with Low Media Contamination Prepared via an Intensified Wet Milling Process,” International Journal of Pharmaceutics (I.F.: 3.458), 2013, under review.
2.      Y. Ying, A. Afolabi, E. Bilgili, Z. Iqbal, “In-line Raman Spectroscopic Monitoring of Size Reduction during Wet Media Milling of BCS Class II Drugs,” Applied Spectroscopy (I.F.: 1.942), 2013, under review.
3.      M. Capece, E. Bilgili, R. Dave, “Formulation of a Physically Motivated Breakage Rate Parameter for Dry Ball Milling via the Discrete Element Method,” AIChE Journal (I.F.: 2.493), 2013, under review.
4.      J. Zhang, Y. Ying, B. Pielecha-Safira, E. Bilgili, R. Ramachandran, R. Romañach, R. Davé, Z. Iqbal, “Raman Spectroscopy for In-line and Off-line Quantification of Poorly Soluble Drugs in Strip Films,” International Journal of Pharmaceutics (I.F.: 3.458), 2013, under review.
5.      A. Afolabi, O. Akinlabi, E. Bilgili, “Impact of Process Parameters on the Breakage Kinetics of Poorly Water-Soluble Drugs during Wet Media Milling: A Microhydrodynamic View,” European Journal of Pharmaceutical Sciences (I.F.: 2.987), Vol. 51, 2014, pp. 75–86.  
6.      A. Bhakay, M. Azad, E. Bilgili, R. Dave, “Redispersible Fast Dissolving Nanocomposite Microparticles of Poorly Water-Soluble Drugs,” International Journal of Pharmaceutics (I.F.: 3.458), Volume 461, 2014, pp. 367–379.
7.      A. Bhakay, M. Azad, E. Vizzotti, R. Dave, E. Bilgili, “Enhanced Recovery and Dissolution of Griseofulvin Nanoparticles from Surfactant-Free Nanocomposite Microparticles Incorporating Wet-Milled Swellable Dispersants,” Drug Development and Industrial Pharmacy (I.F.: 1.539), 2013, DOI: 10.3109/03639045.2013.831442.
8.      A.J. Harrison, E.A. Bilgili, S.P. Beaudoin, L.S. Taylor, “Atomic Force Microscope Infrared Spectroscopy of Griseofulvin Nanocrystals,” Analytical Chemistry (I.F.: 5.695), Vol. 85, 2013, pp. 11449–11455.
9.      M. Azad, A. Afolabi, N. Patel, R. Dave, E. Bilgili, “Preparation of Stable Colloidal Suspensions of Superdisintegrants via Wet Stirred Media Milling,” Particuology (I.F.: 1.419), 2013, DOI: 10.1016/j.partic.2013.07.008.
10. R. Susarla, L. Sievens-Figueroa, A. Bhakay, Y. Shen, J. I. Jerez-Rozo, W. Engen, B. Khusid, E. Bilgili, R. J. Romañach, K. R. Morris, B. Michniak-Kohn, R. N. Davé, “Fast Drying of Biocompatible Polymer Films Loaded with Poorly Water-Soluble Drug Nano-particles via Low Temperature Forced Convection,” International Journal of Pharmaceutics (I.F.: 3.458), Vol. 455, 2013, pp. 93–103.  
11. C. Knieke, M. A. Azad, R. N. Davé, E. Bilgili, “A Study of the Physical Stability of Wet Media-Milled Fenofibrate Suspensions Using Dynamic Equilibrium Curves,” Chemical Engineering Research and Design (I.F.: 1.927), Vol. 91, 2013, pp. 1245–1258.
12. M. Capece, R. Dave, E. Bilgili, “Influence of Non-Linear Breakage Kinetics on the Attainment of Self-Similarity for Dry Milling Processes,” Chemical Engineering Science (I.F.: 2.386), Vol. 97, 2013, pp. 96–107.  
13. R. N. Davé, E. Bilgili, A. Cuitiño, L. Jallo, “Towards Developing Understanding of the Influence of Materials and Processes on Product Performance,” Special Issue on Pharmaceutical Powders, Editorial, Powder Technology (I.F.: 2.024), Vol. 236, 2013, pp. 1–4, Editorial.
14. A. Bhakay, R. Dave, E. Bilgili, “Recovery of BCS Class II Drugs during Aqueous Redispersion of Core-Shell Type Nanocomposite Particles Produced via Fluidized Bed Coating”, Powder Technology (I.F.: 2.024), Vol. 236, 2013, pp. 221–234.
15. C. Beck, L. Sievens-Figueroa, K. Gärtner, J. I. Jerez-Rozo, R. J. Romañach, E. Bilgili, R. N. Davé, “Effects of Stabilizers on Particle Redispersion and Dissolution from Polymer Strip Films Containing Liquid Antisolvent Precipitated Griseofulvin Particles, Powder Technology (I.F.: 2.024), Vol. 236, 2013, pp. 37–51.
16. A. Monteiro, A. Afolabi, E. Bilgili, “Continuous Production of Drug Nanoparticle Suspensions via Wet Stirred Media Milling: A Fresh Look at the Rehbinder Effect,” Drug Development and Industrial Pharmacy (I.F.: 1.539), Vol. 39(2), 2013, pp. 266–283.
17. L. Sievens-Figueroa, N. Pandya, A. Bhakay, G. Keyvan, B. Michniak-Kohn, E. Bilgili, R. N. Davé, “Using USP I and USP IV for Discriminating Dissolution Rates of Nano and Micro Particle Loaded Pharmaceutical Strip-Films,” AAPS Pharmaceutical Science and Technology (I.F.: 1.584), Vol. 13(4), 2012, pp. 1473–1482.
18. E. Bilgili, A. Afolabi, “A Combined Microhydrodynamics–Polymer Adsorption Analysis for Elucidation of the Roles of Stabilizers in Wet Stirred Media Milling,” International Journal of Pharmaceutics (I.F.: 3.458), Vol. 439, 2012, pp. 193–206.
19. E. Bilgili, M. Capece, “A Rigorous Breakage Matrix Methodology for Characterization of Multi-Particle Interactions in Dense-Phase Particle Breakage,” Chemical Engineering Research and Design (I.F.: 1.927), Vol. 90, 2012, pp. 1177–1188.
20. M. Capece, R. Dave, E. Bilgili, “A Rational Function Approximation to the Effectiveness Factor for Multi-Particle Interactions in Dense-Phase Dry Milling,” Powder Technology (I.F.: 2.024), Vol. 230, 2012, pp. 67­–76.
21. L. Sievens-Figueroa, A. Bhakay, J. I. Jerez-Rozo, N. Pandya, R. J. Romañach, B. Michniak-Kohn, Z. Iqbal, E. Bilgili, R. N. Davé, “Preparation and Characterization of Hydroxypropyl Methyl Cellulose Films Containing Stable BCS Class II Drug Nanoparticles for Pharmaceutical Applications,” International Journal of Pharmaceutics (I.F.: 3.458), Vol. 423, 2012, pp. 496–508.
22. E. Bilgili, M. Capece, “Quantitative Analysis of Multi-Particle Interactions during Particle Breakage: a Discrete Non-Linear Population Balance Framework”, Powder Technology (I.F.: 2.024), Vol. 213, 2011, pp.162­–173.
23. M. Capece, E. Bilgili, R. Dave, “Emergence of Falsified Kinetics as a Consequence of Multi-Particle Interactions in Dense-Phase Comminution Processes,” Chemical Engineering Science (I.F.: 2.386), Vol. 66, 2011, pp. 5672–5683.
24. M. Capece, E. Bilgili, R. Dave, “Identification of the Breakage Rate and Distribution Parameters in a Non-Linear Population Balance Model for Batch Milling,” Powder Technology (I.F.: 2.024), Vol. 208, 2011, pp. 195–204.
25. A. Bhakay, M. Merwade, E. Bilgili, R. N. Dave, “Novel Aspects of Wet Milling for the Production of Microsuspensions and Nanosuspensions of Poorly Water-Soluble Drugs,” Drug Development and Industrial Pharmacy (I.F.: 1.539), Vol. 37, 2011, pp. 963–976.

Invited Talks and Seminars



1.     E. Bilgili, “Surfactant-Free Nanocomposite Microparticles as Carriers of BCS Class II Drug Nanoparticles for Fast Redispersion and Dissolution,” Seminar, Host: Dr. Pavol Rajniak, Merck, West Point, PA, July 25, 2013, Invited.
2.    E. Bilgili, “Pharmaceutical Fluidized Bed Granulation: Elements of Process Development for Two Different API Formulations,” Pharmaceutical Development Seminar, Host: Dr. Ilgaz Akseli, Boehringer-Ingelheim Pharmaceuticals, Ridgefield, CT, March 18, 2013, Invited.
3.    E. Bilgili, “Rational Design of Nanocomposite Microparticles for Fast Redispersion and Recovery of Nanoparticles of Poorly Water-Soluble Drugs,” Pharmaceutical Development Seminar, Host: Dr. Ilgaz Akseli, Boehringer-Ingelheim Pharmaceuticals, Ridgefield, CT, May 31, 2012, Invited.
4.     E. Bilgili, “Toward a Rational Design of Nano-Composite Particles for Fast Redispersion and Recovery of Active Nanoparticulate Agents,” Invited Seminar, Host: Dr. Santiago Faucher, Xerox Research Center of Canada, Mississauga, Ontario, Canada, July 13, 2011, Invited.
5.     E. Bilgili, “Fluidized Bed Granulation Technology: A Case Study for High Quality Pharmaceutical Granules,” Invited Talk in September Meeting, AIChE NJ Local Section, Scotch Plains, NJ, September 15, 2010, Invited.
6.     E. Bilgili, R. Dave, “Innovative Particle Engineering for Property Enhancements & Simplification of API Formulations,” Workshop on Nanoparticle Applications to Pharmaceutical Development, Host: Dr. Linda Lohr, Pharmaceutical Development, Pfizer, Groton, CT, May 07, 2010, Invited.
7.     E. Bilgili, “Pharmaceutical Solid Dosage Form Development & Manufacture,” Guidance Counselor Workshop, Panel Speaker in “Career Opportunities in the Biomedical Field - An Industry Perspective”, NJIT, Newark, NJ, May 14, 2010, Invited.
8.     E. Bilgili, "Applications of Particle Technology & Engineering in the Pharmaceutical Industry,” Che445 Particle Technology Special Lecture, Host: Professor Daniel Lepek, Department of Chemical Engineering, Cooper Union, New York, NY, April 08, 2010, Invited.
9.     E. Bilgili, "Structured Nano-Composite Particles for Bioavailability Enhancement of Poorly Water-Soluble Pharmaceutical Compounds," Seminar, Host: Dr. Pavol Rajniak, Merck, West Point, PA, August 05, 2010, Invited.

 

Patents

 

  

 

1.      E. A. Bilgili (Primary Inventor), A. Bhakay, M. Azad, and R. Dave, “System and Method for Superdisintegrant-Based Composite Particles for Dispersion and Dissolution of Agents,” U.S. Patent Application No. 13/829,948, March 14, 2013.
2.      R.N. Davé, D. To, E. Bilgili, M. Azad, C. Knieke, “Pharmaceutical Core-Shell Composite Powder and Processes for Making the Same,” International Patent Application PCT/US 2013/69128 filed, Nov. 08, 2013.
3.      R. N. Dave (Primary Inventor), R. Susarla, E. Bilgili, L. Sievens-Figueroa, B. Khusid, F. Muzzio, R. Chettiannan, and Y. Shen, “System and Method for Fabrication of Uniform Polymer Films Containing Nano and Micro Particles via Continuous Drying Process,” U.S. Provisional Patent, Application No. 61/791,752, March 15, 2013.
4.      G. Ivanov (Primary Inventor), H. Arastoopour, E. Bilgili, N. Shahidi, and B. Bernstein, "Apparatus and Process for Pulverization of a Polymeric Material," U.S. Patent No. 6,513,737, Feb. 4, 2003.                                          
5.      H. Arastoopour (Primary Inventor), D. A. Schocke, B. Bernstein, and E. Bilgili, "Process for Recycling of Rubber Materials," U.S. Patent No. 5,904,885, May 18, 1999.