Academic Interests: powder technology, particle engineering, pharmaceutical solids manufacturing technology, rubber elasticity, finite thermoelasticity, rubber processing, recycling, healthcare science and engineering,
Ecevit Bilgili received his B.S. degree in chemical engineering from Bogazici University in Istanbul, Turkey in 1996 at the top of his class. He received his Ph.D. degree in chemical engineering from the Illinois Institute of Technology, Chicago in May 2001. The PhD work led to the Best PhD Thesis Award by the Particle Technology Forum of AIChE in 2004. The work, which was multi-disciplinary by nature, shed fundamental light on the mechano-chemical nature of a novel rubber recycling process. Between 2001 and late 2004, Dr. Bilgili worked as a post-doctoral research associate at the Particle Engineering Research Center, University of Florida. His research interests centered on the processing, characterization, and modeling of particulate unit operations and powders. The experimental and theoretical work focused on powder flow in shear testers, nanoparticle production via stirred media milling as well as population balance modeling of size reduction operations.
- Ph.D.(May 2001), Chemical Engineering., Illinois Institute of Technology, Chicago, IL.
- B.S.(June 1996), Chemical Engineering., Bogazici University, Istanbul, Turkey.
Honors and Awards
- PCT & GPC Operations Technology Mastery Award, by Merck & Co., in recognition of the efforts towards developing the fluid bed granulation technology, 2009
- Marquis Who´s Who in Science and Engineering appeared in the 7th, 9th, and 10th Eds., 2003–2004, 2006–2007, and 2008–2009.
- Award of Excellence, by Merck & Co., Inc. in recognition of significant contributions to a drug development program, 2008
- Marquis Who´s Who of Emerging Leaders, appeared in the 1st Ed., 2006–2007
- Award of Excellence, by Merck & Co., Inc. in recognition of significant contributions to an accelerated drug filing, 2006
- Special Achievement Award, by Merck & Co., Inc. in recognition of personal dedication and technical contributions to a drug development program, 2005
- Best Ph.D. Thesis in Particle Technology Award, by Particle Technology Forum of the American Institute of Chemical Engineers, 2004
- Marquis Who´s Who in America, appeared in the 56th, 57th, and 58th Editions, 2002, 2003, and 2004
- Certificate of The Highest Standards of Academic Achievement given by IIT, Chicago, 2001
- Who´s Who Among Students in American Universities and Colleges, 1998–2001
- The Professor Turgut Noyan Award given by the Chemical Engineering Department, Bogazici University, 1996
Courses I Teach
Professor Bilgili’s general research area is Particle Science and Engineering as applied to high-value-added product industries such as pharmaceuticals, diagnostic agents, nutraceuticals, agrochemicals, inks, etc. with a primary focus on pharmaceuticals and health sciences.
- Poor water-solubility and inadequate bioavailability of more than 40% of the newly discovered drugs, which prevents or delays formulation development and commercialization
- Inability to prepare and stabilize sub100 nm drug particles in suspensions, which is a barrier to bioavailability enhancement and sterile filtration of drug nanoparticle suspensions
- Excessive use of surfactants and sugars in nanoparticulate drug formulations
- Lack of predictive tools/models for production of drug nanoparticles and their composites
- Poor understanding of non-linear effects, mechanical multi-particle interactions, and empirical nature of kernels in population balance modeling
- Develop a fundamental understanding of the controlling mechanical/physico-chemical parameters and mechanisms by which drug nanoparticles, especially ones with sub-100 nm particles, can be produced.
- Elucidate the dynamics and mechanisms by which active nanoparticles are recovered from solid dosage forms such as nanocomposite microparticles (NCMPs), strip films, and tablets during wet dispersion/dissolution in physiologically relevant fluids.
- Develop a mechanistic understanding of the functional responses of active (drug) agent-carrying solid dosage forms via process–structure–property–performance interrelationships
- Extend/apply the fundamental learning and research findings from the pharmaceuticals-centric (drug) research to other active agents like agrochemicals, biological agents, etc.
- Develop mechanistic, particle-scale kernels for population balance models that allow for multi-scale modeling of particle formation processes and elucidation of the elusive non-linear effects
Recent Peer Refereed Journal Papers (Lead author underlined)
Invited Talks and Seminars