Rajesh N. Dave

Contact Info

Title: Distinguished Professor
Email: rajesh.n.dave@njit.edu
Office: 308 YCEES
Phone: 973-596-5860
Dept: Chemical Engineering

About Me

Rajesh N. Davé is a distinguished professor in the Otto H. York Department of Chemical, Biological and Pharmaceutical Engineering.

He is the founding Director of the R&D Excellence Center, New Jersey Center for Engineered Particulates, focusing on research and innovations in particle engineering for improved particle properties for applications to pharmaceutical, food, electronics, and energy industries. Under his direction, the center has developed into an important resource for researchers and industry alike in the areas of nanoparticles and nanocomposites. The center is equipped with state-of-the-art equipment for processing and characterizing particles at the nano and submicron levels, and researchers work in partnership with industry to develop tailored particulate materials with unique properties for industry applications. Center research in particle engineering has led to attracting funds from National Science Foundation, National Institute of Health, and other federal agencies as well as industry. These activities have also led to NJIT’s first ever participation in an NSF funded Engineering Research Center on Structured Organic Particulate Systems with a focus on improved materials and manufacturing science for pharmaceutical products. In this NSF-ERC, Prof. Davé is a Site Leader, a Research Thrust Leader and a leader of a particle engineering based technology platform Testbed on drug laden thin films.

His NSF-ERC leadership roles have led to significant impact on pharmaceutical industry through aligning high quality research with the NAE and NIH goals that include better medicines, medications the body can absorb and process efficiently, and designing therapies and dosages that are more precise and flexible. These advancements are expected to have a broad societal impact through improved patient care, patient compliance and comfort and reduced manufacturing costs. Ongoing commercialization activities of transformative technologies are expected to make an impact in a long run at a level of over $B per year.

His research contributions to date include over 150 journal papers, numerous invited and keynote presentations as well as nine issued and about dozen pending patents. His current research expertise includes engineered particulates with special emphasis on pharmaceuticals products. He has granted 29 PhDs to students at NJIT, six of those students are currently in US academia. He has received numerous awards, most recently, 2015 AIChE PTF Lectureship Award in Fluidization. He has also been engaged in technology development and transfer activities in film coating of very fine particles, bioavailability enhancement, and taste-masking. His work on taste-masking via solventless coating technology has been commercially licensed by a global pharma company.

Education

  • Utah State University, PhD 1983
  • Utah State University, MS.1981
  • Indian Institute of Technology Bombay, BTech 1978

Professional Activities

  • Executive Editor, US Editorial Board: Advanced Powder Technology (2015 – current)
  • Chair, AIChE/Particle Technology Forum, 2017-2019.
  • Vice-Chair, AIChE/Particle Technology Forum, 2015-2017.
  • Advisory Board, WCPT 2018 - Eighth World Congress on Particle Technology, April 22-26, 2018, Orlando, Florida, USA.
  • Member, Executive Committee, AIChE/Particle Technology Forum, 2012-2016.
  • Chair, Area 3D, Nanoparticles, AIChE/Particle Technology Forum, 2002-2004.
  • Chair, Area 3A, Particle Production and Characterization, AIChE/Particle Technology Forum, 2004-2006.
  • Associate EditorIEEE Transactions on Fuzzy Systems, 1997-2002.
  • General Chair, NAFIPS’99 – 18th International Conference of the North American Fuzzy Information Processing Society, New York City, June 1999.

Awards and Honors

  • Board of Overseers Excellence in Research Prize and Medal, New Jersey Institute of Technology, 6th October 2016.
  • 2016 Thomas Alva Edison Patent Award Winner, Enabling Technology, November 3, 2016.
  • New Jersey Inventors Hall of Fame 2015 Innovators Award.
  • 2015 American Institute of Chemical Engineers (AIChE) Particle Technology Forum (PTF) Lectureship Award in Fluidization.
  • Excellence in Research Award (Newark College of Engineering), NJIT, September 2008
  • Designation as NJIT Master Teacher, September 2008 
  • Robert W. Van Houten Award for Excellence in Teaching, NJIT, 2004
  • Teaching Excellence Award in Category of Upper Undergraduate Level, NJIT, Fall 2003.
  • Newark College of Engineering Innovation in Engineering Education Award for 1999.
  • K. S. Fu Award from North American Fuzzy Information Processing Society (NAFIPS), June 1999.

 

Current Research Interests

Particle Technology: Modeling and development of novel techniques for dry particle coating and manufacturing of engineered particles. Ultrafine particle mixing using dry methods. Discrete Element Modeling (DEM) and numerical simulations of particle flows and processes. Granulation with minimal use of liquids. Particle transport and handling/Flow and delivery from hoppers. Some of the past projects include: Development of non-intrusive particle tracing technique for granular flow experiments. Development of motion analysis algorithms for high speed optical imaging of three-dimensional particle collisions. Pattern recognition and cluster analysis techniques to detect micro-structure in granular flows.

Pattern Recognition/Cluster Analysis/Image Processing : Research includes fuzzy clustering algorithms, robust clustering, clustering of relational data, application of robust statistical techniques in cluster analysis, shape detection in noisy data, generalization of fuzzy clustering algorithms for multi-characteristic shape detection, e.g. hyper-spherical/ellipsoidal shells as cluster prototypes, or adaptive clustering. Issues of cluster validity are also addressed. Clustering methods and evidence collection techniques are used for lines, curves and arc detection in digital images. These algorithms are also used in reverse engineering through development of CAD models from image sensor data. Machine vision applications are also considered.

 

Selected Publications

R. B. Patel, J. Liu, J. V. Scicolone, S. Roy, S. Mitra, R. N. Davé, Z. Iqbal, “Formation of Stainless Steel-Carbon Nanotube Composites using a Scalable Chemical Infiltration Process,” Journal of Materials Research, February 2013, Volume 48, Issue 3 , 1387-1395, DOI: 10.1007/s10853-012-6885-1

Chinmay Ghoroi, Xi Han, Daniel To, Laila Jallo, Lakxmi Gurumurthy, Rajesh N. Davé, “Dispersion of ultrafine powders through surface modification or rapid expansion,” Chemical Engineering Science, Special Issue (Ed. F. Saito), January 2013, Volume 85, 11-24, doi:10.1016/j.ces.2012.02.038

Lucas Sievens-Figueroa, Natasha Pandya, Anagha Bhakay, Golshid Keyvan, Bozena Michniak-Kohn, Ecevit Bilgili, Rajesh N. Davé, “Using USP I and USP IV for discriminating dissolution rates of nano and micro particle loaded pharmaceutical strip-films”,  AAPS PharmSciTech, January 2013, Volume 13, Issue 4 , 1473-1482, DOI: 10.1208/s12249-012-9875-3

Maxx Capece, Rajesh Davé, Ecevit Bilgili, “A Rational Function Approximation to the Effectiveness Factor for Multi-Particle Interactions in Dense-Phase Dry Milling,” Powder Technology, November 2012, Volume 230, 6776. doi:10.1016/j.powtec.2012.06

Rajesh N. Davé, Ecevit Bilgili, Alberto Cuitiño, Laila Jallo, “Special Issue on Pharmaceutical Powders: Towards Developing Understanding of the Influence of Materials and Processes on Product Performance,” Powder Technology, An Editorial, 2012, doi:10.1016/j.powtec.2012.09.005

Xi Han, Chinmay Ghoroi, Rajesh Davé, “Dry coating of micronized API powders for improved dissolution of directly compacted tablets with high drug loading,” International Journal of Pharmaceutics, Special Issue: Mechanical Properties of Drug Tablets, Accepted August 2012. 10.1016/j.ijpharm.2012.08.004

Dave K. Balachandran, Laila J. Jallo, Rajesh N. Davé, Stephen P. Beaudoin, “Adhesion of Dry Nano-Coated Particles to Stainless Steel: A Physical Interpretation”, Powder Technology, 226, pp. 1-9, 2012. doi: 10.1016/j.powtec.2012.02.035.

Christian Beck , Lucas Sievens-Figueroa, Konstantin Gärtner, Jackeline I. Jerez-Rozo, Rodolfo J. Romañach, Ecevit, Bilgili and Rajesh N. Davé, “Effects of stabilizers on particle redispersion and dissolution from polymer strip films containing liquid antisolvent precipitated griseofulvin particles,” Powder Technology, Special Issue: Pharmaceutical Powders, doi:10.1016/j.powtec.2012.05.047. (accepted  May 2012)

Anna Łuczak, Laila J. Jallo, Rajesh N. Dave, Zafar Iqbal, “Polymorph Stabilization in Processed Acetaminophen Powders,” Powder Technology, Special Issue: Pharmaceutical Powders, doi:10.1016/j.powtec.2012.05.046. (accepted  May 2012)

Sameer Dalvi, Mohammad Azad, Rajesh N. Davé, “Precipitation and Stabilization of Ultrafine Particles of Fenofibrate in Aqueous Suspensions by RESOLV,” Powder Technology, Special Issue: Pharmaceutical Powders, doi:10.1016/j.powtec.2012.05.038. (accepted May 2012)

Chinmay Ghoroi, Lakxmi Gurumurthy, D. J. McDaniel, Laila Jallo, Rajesh N. Davé, “Multi-faceted characterization of flow, packing and fluidization properties of pharmaceutical powders to discern the influence of surface modification,” Powder Technology, Special Issue: Pharmaceutical Powders, doi:10.1016/j.powtec.2012.05.039, (accepted  May 2012)

Wusheng Zhu, Francis S Romanski, Sameer V Dalvi, Rajesh N. Davé, M. Silvina Tomassone, “Atomistic Simulations of Aqueous Griseofulvin Crystals in the Presence of Individual and Multiple Additives,” Chemical Engineering Science, 73, 2012, 218–230, May 2012,  http://dx.doi.org/10.1016/j.ces.2012.01.008

L. Sievens-Figueroa, A. Bhakay, J. I. Jerez-Rozo, N. Pandya, R. Romanach, B. Michniak-Kohn, Z. Iqbal, E. Bilgili, R. N. Davé, “Preparation and characterization of hydroxypropyl methyl cellulose films containing stable BCS Class II drug nanoparticles for pharmaceutical applications,” International Journal of Pharmaceutics, February 2012,Volume 423, Issue 2, 496– 508,  doi:10.1016/j.ijpharm.2011.12.001

Laila J. Jallo, Chinmay Ghoroi, Lakxmi Gurumurthy, Utsav Patel, Rajesh N. Davé, “Improvement of flow and bulk density of pharmaceutical powders using surface modification,” International Journal of Pharmaceutics, 423, February 2012, 213– 225, doi:10.1016/j.ijpharm.2011.12

Anagha Bhakay, Ecevit Bilgili, Rajesh Davé, “Recovery of BCS Class II drugs during aqueous redispersion of core-shell type nanocomposite particles produced via fluidized bed coating,” Powder Technology,” Special Issue: Pharmaceutical Powders, doi 10.1016/j.powtec.2011.12.066, 2012.

Amit Banerjee, Rajesh N. Davé, “Robust Clustering,” Wiley Interdisciplinary Reviews: Data Mining and Knowledge Discovery, Volume 2, Issue 1, pp 29-59, 2012 http://onlinelibrary.wiley.com/doi/10.1002/widm.49/abstract

Maxx Capece, Ecevit Bilgili, Rajesh Davé, “Emergence of falsified kinetics as a consequence of multi-particle interactions in dense-phase comminution processes,” Chemical Engineering Science, 2011, Volume 66, Issue 22, Pages 5672-5683, 15 November 2011, http://www.sciencedirect.com/science/article/pii/S0009250911005318

Matthew P. Mullarney, Lauren E. Beach, Rajesh N. Davé, Beth A. Langdon, Mark Polizzi, Daniel O. Blackwood, “Applying dry powder coatings to pharmaceutical powders using a comil for improving powder flow and bulk density,” Powder Technology, Vol. 212, Issue 3,397402, October 2011, doi:10.1016/j.powtec.2011.06.008.

Daniel To, Rajesh N. Davé, Sankaran Sundaresan, “Nano-particle Mixing through Rapid Expansion of High-Pressure and Supercritical Suspensions,” Journal of Nanoparticle,Research, Volume 13, Issue 9 September 2011, Page 4253-4266, DOI:10.1007/s11051-011-0369-0

Xi Han, Chinmay Ghoroi, Daniel To; Yuhua Chen, Rajesh N. Davé, "Simultaneous micronization and surface modification for improvement of flow and dissolution of drug particles,” International Journal of Pharmaceutics, Volume 415, Issue 1-2,185– 195, August 2011. http://dx.doi.org.libdb.njit.edu:8888/10.1016/j.ijpharm.2011.05.070

John Carpinelli, Howard Kimmel, Linda Hirsch, Levelle Burr-Alexander, Albert Narh, Rajesh N. Davé, “Translating research experiences into classroom practice: An RET Project,” 11th ASEE Annual Conference and Exposition, June 2011, 18p,

Anagha Bhakay, Maneesh Merwade, Ecevit Bilgili, and Rajesh N. Davé, “Novel Aspects of the Wet Media Milling for the Production of Microsuspensions and Nanosuspensions of Poorly Water-Soluble Drugs,” Drug Development and Industrial Pharmacy, August 2011, Volume 37, Issue 8, 963-976, http://informahealthcare.com/doi/abs/10.3109/03639045.2010.551775

Maxx Capece, Rajesh N. Davé, “Application of Fluidized Bed Film Coating for Membrane Encapsulation of Catalysts,” Powder Technology,  August 2011, Volume 211, Issues 2-3,  Pages 199-206.http://dx.doi.org.libdb.njit.edu:8888/10.1016/j.powtec.2011.04.015

James Scicolone, Ajit Mujumdar, Sankaran Sundaresan, and Rajesh N. Davé, “Environmentally Benign Dry Mechanical Mixing of Nano-particles using Magnetically Assisted Impaction Mixing Process,” Powder Technology, Volume 209, Issues 1-3, May 2011, Pages 138-146, http://dx.doi.org.libdb.njit.edu:8888/10.1016/j.powtec.2011.02.021

Maxx Capece, Ecevit Bilgili, Rajesh Davé, “Identification of the Breakage Rate and Distribution Parameters in a Non-linear Population Balance Model for Batch Milling,” Powder Technology, 208 (1), pp. 195-204, March 2011. http://dx.doi.org.libdb.njit.edu:8888/10.1016/j.powtec.2010.12.019

Laila J. Jallo, Yuhua Chen, James Bowen, Frank Etzler, and Rajesh Davé, “Prediction of Inter-particle Adhesion Force from Surface Energy and Surface Roughness,” Journal of Adhesion Science and Technology, Vol. 25, Issue 4-5, January 2011, 367-384. http://www.tandfonline.com.libdb.njit.edu:8888/doi/abs/10.1163/016942410X525623

A. Banerjee, R. Dave, “A context-sensitive crossover operator for clustering applications,” 2010 IEEE World Congress on Computational Intelligence, July2010.

Laila J. Jallo, Mirko A. Schoenitz, Edward L. Dreizin, Rajesh N. Davé, and Curtis E. Johnson, “The effect of surface modification of aluminum powder on its flowability, combustion and reactivity,”,Powder Technology, Vol. 204, pp. 63-70, 2010. doi:10.1016/j.powtec.2010.07.017

Christian Beck, Sameer V. Dalvi, Rajesh Davé, “Controlled Liquid Antisolvent Precipitation of Drug Particles using a Rapid Mixing Device,” Chemical Engineering Science, 65 (2010) 5669–5675. DOI: 10.1016/j.ces.2010.04.001

Yuhua Chen, Laila Jallo, Miguel A. S. Quintanilla and Rajesh Davé, “Characterization of Particle and Bulk Level Cohesion Reduction of Surface Modified Fine Aluminum Powders,” Colloids and Surfaces A: Physicochemical and Engineering Aspects, Vol. 361, pp. 66-80, April 2010. .http://dx.doi.org.libdb.njit.edu:8888/10.1016/j.colsurfa.2010.03.015

Sameer V. Dalvi and Rajesh N. Davé, “Analysis of Nucleation Kinetics of Poorly Water Soluble Drugs in presence of Ultrasound and Hydroxypropyl Methyl Cellulose during Antisolvent Precipitation,” International Journal of Pharmaceutics, Vol. 387 (1 & 2), pp. 172–179, March 2010. DOI: 10.1016/j.ijpharm.2009.12.026

Lauren Beach, Jorge Ropero, Ajit Mujumdar, Manel Alcalà, Rodolfo J. Romañach, Rajesh N. Davé, “Near-infrared Spectroscopy for the In-line Characterization of Powder Voiding, Part II: Quantification of Enhanced Flow Properties of Surface Modified Active Pharmaceutical Ingredients,” Journal of Pharmaceutical Innovation, Volume 5, Numbers 1-2, July 2010. 1.http://link.springer.com/article/10.1007%2Fs12247-010-9075-1

D. Lepek, J.M. Valverde, R. Pfeffer, A. Castellanos, R.N. Davé, “Enhanced Nanofluidization by Alternating Electric Fields,” AIChE Journal, Cover Article, Vol 56(1), p 54-65, January 2010. DOI: 10.1002/aic.11954

Qi Zhang, Jun Yang, Shuli Teng, Rajesh N. Dave, Linjie Zhu, Peng Wang, Ming-Wan Young, Costas G. Gogos, “In-situ, Simultaneous Milling and Coating of Particulates with Nano-particles,” Powder Technology, 196,3 (2009) 292–297. doi:10.1016/j.powtec.2009.08.011

Jorge Ropero, Lauren Beach, Manel Alcalà, Raizza Rentas, , Rajesh N. Davé, Rodolfo J. Romañach, “Near-infrared Spectroscopy for the In-line Characterization of Powder Voiding, Part I: Development of the Methodology,” Journal of Pharmaceutical Innovation, Volume 4, Issue 4, pp 187-197, December 2009. DOI: 10.1007/s12247-009-9069-

Daniel To, Rajesh Davé, Xiaolong Yin, Sankaran Sundaresan “Deagglomeration of nanoparticle aggregates via rapid expansion of supercritical or high-pressure suspensions,”AIChE Journal, Vol. 55 (11), pp. 2807-2826, 2009. http://onlinelibrary.wiley.com.libdb.njit.edu:8888/doi/10.1002/aic.11887/abstract

Sameer V. Dalvi and Rajesh N. Davé, “Controlling particle size of a poorly water-soluble drug using ultrasound and stabilizers in antisolvent precipitation,”Industrial and Engineering Chemistry Research, Vol. 48 (16), pp 7581–7593, July 2009, DOI: 10.1021/ie900248f.

Xianjin Jiang, Mikhaylo A. Trunov, Mirko Schoenitz, Rajesh N. Davé, and Edward L. Dreizin, “Mechanical Alloying and Reactive Milling in a High Energy Planetary Mill,” Journal of Alloys and Compounds, Volume 478, Issues 1-2, 10, Pages 246-251, June 2009. http://dx.doi.org.libdb.njit.edu:8888/10.1016/j.jallcom.2008.12.021.

H. Kimmel, L. S. Hirsch, L. Simon, L. Burr-Alexander, R. N. Davé, “Implementing Concepts of Pharmaceutical Engineering into High School Science Classrooms,” Chemical Engineering Education, Vol. 43, No. 3, pp. 187-193, June 2009

Yuhua Chen, Jun Yang, Rajesh N. Davé and Robert Pfeffer, “Granulation of Cohesive Geldart Group C Powders in a Mini-Glatt Fluidized Bed by pre-coating with nanoparticles,” Powder Technology, 191 (1-2), April (2009) 206–217, doi:10.1016/j.powtec.2008.10.010

Yuhua Chen, M. A. S. Quintanilla, Jun Yang, Jose M. Valverde and Rajesh N. Davé, “Pull-off Force of Coated Fine Powders under Small Consolidation,” Physical Review E, 79 (4), pp. art no. 041305April 2009. http://link.aps.org/doi/10.1103/PhysRevE.79.041305

Yuhua Chen, Jun Yang, A. Mujumdar, Rajesh N. Davé, “Fluidized Bed Film Coating of Cohesive Geldart Group C Powders,” Powder Technology, 189, February (2009) 466–480 doi:10.1016/j.powtec.2008.08.002

Ganesh P. Sanganwar, Ram Gupta. Alexandre Ermoline, James V. Scicolone, Rajesh N. Davé, “Environmentally Benign Nano-mixing by Sonication in high-pressure CO2,” Journal of Nanoparticle Research, Volume 11, Issue 2, February (2009), Page 405. doi: 10.1007/s11051-008-9394-z

D. Lepek, R. Pfeffer, Rajesh Davé, M.A.S. Quintanilla, J.M. Valverde, A. Castellanos, “Nanofluidization as affected by vibration and electrostatic fields,” AIChE Annual meeting, 2008

James Scicolone, Rajesh Davé, “Fluidized bed mixing of nanosized particles,” AIChE Annual meeting, 2008

James Scicolone, Rajesh Davé, “Comparing mixing quality of nanosized particles by environmentally benign mixing techniques,” AIChE Annual meeting, 2008

Lauren Beach, J. Ropero, M. Alcala, R. Romanch, Rajesh Davé, “ In-process characterization of coated pharmaceutical powder blends using NIR spectroscopy,” AIChE Annual meeting, 2008

James Scicolone, A. Mujumdar, Rajesh Davé, “Mixing of nanosized particles by magnetically assisted impaction mixing in dry and fluid suspension,” AIChE Annual meeting, 2008

Howard Kimmel , Linda Hirsch , L. Simon., L. Burr-Alexander., Rajesh Davé, “Implementing concepts of pharmaceutical engineering into high school science classrooms,” AIChE Annual meeting2008

X. Jiang , M.A. Trunov., M. Schoenitz , Rajesh Davé, Ed. Dreizin , “Mechanical alloying and reactive milling in a high energy planetary mill,” 44th AIAA/ASME/SAE/ASEE Joint Propulsion Conference and Exhibit, 2008

L. Beach, Y. Chen, L. Jallo, A. Mujumdar, Rajesh Davé, “Properties and characterization of pharmaceutical powders modified by dry coating,” AIChE Annual meeting, 2008

C. G. Gogos, M. Young M.., L. Zhu, C. Wan, Rajesh Davé, D. Todd, “A novel net shape manufacturing process for concentrated polymer-particulate composite products,” Technical papers, Reginal Technical conference, 2008

M.A.S. Quintanilla, J.M. Valverde, A. Castellanos, , R. Pfeffer, and R. N. Davé, “Nano fluidization as affected by vibration and electrostatic fields,” Chemical Engineering Science, Volume 63, Issue 22, November 2008, Pages 5559-5569, DOI: 10.1016/j.ces.2008.08.012

Jose Quevedo, Gaurav Patel, Robert Pfeffer, Rajesh Davé, “Agglomerates and granules of nanoparticles as filter media for submicron particles,”  Powder Technology 183 (3), pp. 480-500 (2008), doi: 10.1016/j.powtec.2008.01.020

Yuhua Chen, Jun Yang, Rajesh N. Davé and Robert Pfeffer, “Fluidization of Coated Group C Powders,” AIChE Journal, Volume 54, Issue 1, pp. 104-121, January 2008. http://onlinelibrary.wiley.com.libdb.njit.edu:8888/doi/10.1002/aic.11368/abstract

J. M. Valverde, M. A. S. Quintanilla, A. Catellanos, Daniel Lepek, R. N. Davé, R. Pfeffer, “Fluidization of fine and ultrafine particles using nitrogen and neon as fluidizing gases,” AIChE Journal, Volume 54, Issue 1, pp. 86-103, January 2008. http://onlinelibrary.wiley.com.libdb.njit.edu:8888/doi/10.1002/aic.11329/abstract