Rajesh N. Dave

Contact Info

Title: Distinguished Professor
Email: rajesh.n.dave@njit.edu
Office: 308 YCEES
Phone: 973-596-5860
Dept: Chemical Engineering

About Me

Distinguished professor Rajesh N. Davé is the founding director of the New Jersey Center for Engineered Particulates, in the Otto H. York Department of Chemical, Biological and Pharmaceutical Engineering, focusing on creation of advanced particulate materials and products through particle engineering. 

He focuses on research and innovations in particle engineering for improved particle properties for applications to pharmaceutical, food, electronics, and energy industries. Under his direction, the center has developed into an important resource for researchers and industry alike in the areas of nanoparticles and nanocomposites. The center is equipped with state-of-the-art equipment for processing and characterizing particles at the nano and submicron levels, and researchers work in partnership with industry to develop tailored particulate materials with unique properties for industry applications. Center research in particle engineering has led to attracting funds from National Science Foundation, National Institute of Health, and other federal agencies as well as industry. These activities have also led to NJIT’s first ever participation in an NSF funded Engineering Research Center on Structured Organic Particulate Systems with a focus on improved materials and manufacturing science for pharmaceutical products. In this NSF-ERC, Prof. Davé is a Site Leader, a Research Thrust Leader and a leader of a particle engineering based technology platform Testbed on drug laden thin films.

His NSF-ERC leadership roles have led to significant impact on pharmaceutical industry through aligning high quality research with the NAE and NIH goals that include better medicines, medications the body can absorb and process efficiently, and designing therapies and dosages that are more precise and flexible. These advancements are expected to have a broad societal impact through improved patient care, patient compliance and comfort and reduced manufacturing costs. Ongoing commercialization activities of transformative technologies are expected to make an impact in a long run at a level of over $B per year.

His research contributions to date include over 150 journal papers, numerous invited and keynote presentations as well as 11 issued and about dozen pending patents. His current research expertise includes engineered particulates with special emphasis on pharmaceuticals products. He has granted 29 PhDs to students at NJIT, six of those students are currently in US academia. He has received numerous awards, most recently, the Board of Overseers Excellence in Research Prize and Medal, NJIT, October 2016 and the Thomas Alva Edison Patent Award Winner, Enabling Technology, November 2016. He has also been engaged in technology development and transfer activities in film coating of very fine particles, bioavailability enhancement, and taste-masking. His work on taste-masking via solventless coating technology has been commercially licensed by a global pharma company.

Education

  • Utah State University, PhD 1983
  • Utah State University, MS.1981
  • Indian Institute of Technology Bombay, BTech 1978

Professional Activities

  • Executive Editor, US Editorial Board: Advanced Powder Technology (2015 – current)
  • Chair, AIChE/Particle Technology Forum, 2017-2019.
  • Vice-Chair, AIChE/Particle Technology Forum, 2015-2017.
  • Advisory Board, WCPT 2018 - Eighth World Congress on Particle Technology, April 22-26, 2018, Orlando, Florida, USA.
  • Member, Executive Committee, AIChE/Particle Technology Forum, 2012-2016.
  • Chair, Area 3D, Nanoparticles, AIChE/Particle Technology Forum, 2002-2004.
  • Chair, Area 3A, Particle Production and Characterization, AIChE/Particle Technology Forum, 2004-2006.
  • Associate EditorIEEE Transactions on Fuzzy Systems, 1997-2002.
  • General Chair, NAFIPS’99 – 18th International Conference of the North American Fuzzy Information Processing Society, New York City, June 1999.

Awards and Honors

  • Board of Overseers Excellence in Research Prize and Medal, New Jersey Institute of Technology, 6th October 2016.
  • 2016 Thomas Alva Edison Patent Award Winner, Enabling Technology, November 3, 2016.
  • New Jersey Inventors Hall of Fame 2015 Innovators Award.
  • 2015 American Institute of Chemical Engineers (AIChE) Particle Technology Forum (PTF) Lectureship Award in Fluidization.
  • Excellence in Research Award (Newark College of Engineering), NJIT, September 2008
  • Designation as NJIT Master Teacher, September 2008 
  • Robert W. Van Houten Award for Excellence in Teaching, NJIT, 2004
  • Teaching Excellence Award in Category of Upper Undergraduate Level, NJIT, Fall 2003.
  • Newark College of Engineering Innovation in Engineering Education Award for 1999.
  • K. S. Fu Award from North American Fuzzy Information Processing Society (NAFIPS), June 1999.

 

Current Research Interests

Engineered Particulates: Particle engineering for property enhancement and formation of nano-particles and structured particle composites, including films, for applications such as pharmaceutical, food, electronic and energetic materials. Pharmaceutical formulations for improved dosage forms and their performance. Development of novel techniques for dry particle coating, film-coated particles, granules and engineered particulates. Taste-masking and controlled release of fine API particles via mechanical and fluidized bed processes.  Characterization of particle adhesion and powder flow. Improvement of powder flow via surface modification. Formation of stable nano and micro suspensions of poorly water-soluble drug particles for drug delivery applications.  Nano-particle mixing, and nano-particle fluidization. Supercritical fluid processing for particle mixing, coating and particle formation. Particle transport and handling/Flow and delivery from hoppers. Numerical simulations including discrete element modeling of particle processes. 


Pattern Recognition / Cluster Analysis: Fuzzy sets in clustering. Robust clustering. Clustering of relational data. Application of robust statistical techniques in cluster analysis. Shape detection in noisy data. Generalization of algorithms for multi-characteristic shape detection, e.g. hyper-spherical/ellipsoidal shells as cluster prototypes. Adaptive clustering. Cluster validity. Image analysis using fuzzy pattern recognition. Neural networks/fuzzy adaptive networks. 
 

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  1. M. Capece, R. N. Davé, E. Bilgili, “A Pseudo-coupled DEM–Non-linear PBM Approach for Simulating the Evolution of Particle Size during Dry Milling”, Powder Technology
     
  2. A. Bhakay, E. Bilgili, R. Davé, “Quiescent and Agitated Redispersion as a Tool for Evaluating Dispersant Effectiveness in Dissolution Enhancement of Drug-Laden Nanocomposites”, AAPS Pharmaceutical Science and Technology
     
  3. M. Azad, J. Moreno, R. Davé, “Stable and Fast-Dissolving Amorphous Drug Composites Preparation via Impregnation of Neusilin® UFL2”, Journal of Pharmaceutical Sciences
     
  4. Z. Huang, W. Xiong, X. Deng, S. Bhaumik, R. N. Davé, “Improving blend content uniformity via dry particle coating of micronized drug powders”, European Journal of Pharmaceutical Sciences, 104:344–355, 2017
     
  5. X. Deng, R. N. Davé, “Adhesion and friction of dry-coated nano-rough particles”, Powder Technology, Special Issue: Modelling & Simulation, 314:20-27, 2017
     
  6. Y. Ying, C. Beck, A. Wu, R. Davé, Z. Iqbal, “Polymorph formation in fenofibrate in the absence and presence of polymer stabilizers: A low frequency Raman and differential scanning calorimetry study”, Journal of Raman Spectroscopy, 48(5):750-757, 2017
     
  7. S. M. Krull, J. Moreno, M. Li, E. Bilgili, R. N. Davé, “Critical material attributes (CMAs) of strip films loaded with poorly water-soluble drug nanoparticles: III. Impact of drug nanoparticle loading”, International Journal of Pharmaceutics, 523(1):33-41, 2017
     
  8. X. Deng, R. N. Davé, “Properties of force networks in jammed granular media”, Granular Matter, 19(2):27, 2017
     
  9. M. Capece, Z. Huang, R. Davé, “Insight into a Novel Strategy for the Design of Tablet Formulations Intended for Direct Compression”, Journal of Pharmaceutical Sciences, 106(6):1608-1617, 2017
     
  10. X. Deng, R. N. Davé, “Breakage of fractal agglomerates”, Chemical Engineering Science, 161(6):117-126, 2017
     
  11. S. M. Krull, J. Ammirata, S. Bawa, M. Li, E. Bilgili, R. Davé, “Critical material attributes (CMAs) of strip films loaded with poorly water-soluble drug nanoparticles: II. Impact of polymer molecular weight”, Journal of Pharmaceutical Sciences, 106(2):619-628, 2017
     
  12. M. Azad, J. Moreno, E. Bilgili, R. Davé, “Fast Dissolution of Poorly Water Soluble Drugs from Fluidized Bed Coated Nanocomposites: Impact of Carrier Size”, International Journal of Pharmaceutics, 513(1-2):319-331, 2016
     
  13. X. Deng, Z. Huang, W. Wang, R. N. Davé, “Investigation of nanoparticle agglomerates properties using Monte Carlo simulations”, Advanced Powder Technology, 27(5):1971-1979, 2016
     
  14. S. M. Krull, H. V. Patel, M. Li, E. Bilgili, R. Davé, “Critical material attributes (CMAs) of strip films loaded with poorly water-soluble drug nanoparticles: I. Impact of plasticizer on film properties and dissolution”, European Journal of Pharmaceutical Sciences, 92:146-155, 2016
     
  15. M. Li, M. Azad, R. Davé, E. Bilgili, “Nanomilling of Drugs for Bioavailability Enhancement: A Holistic Formulation–Process Perspective”, Pharmaceutics, (8):17, 2016
     
  16. S. M. Krull, Zhelun Ma, M. Li, R. N. Davé, E. Bilgili, “Preparation and characterization of fast dissolving pullulan films containing BCS Class II drug nanoparticles for bioavailability enhancement”, Drug Development and Industrial Pharmacy, 42(7):1073-1085, 2016
     
  17. D. To and R. N. Davé, “Fluid bed film coating of fine ibuprofen particles”, Powder Technology, 290:102–113, 2016
     
  18. A. Bhakay, E. Vizzotti, M. Li, R. Davé, E. Bilgili, “Incorporation of Fenofibrate Nanoparticles Prepared by Melt Emulsification into Polymeric Strip Films”, Journal of Pharmaceutical Innovation, 11:53–63, 2016
     
  19. M. Li, L. Zhang , R. N. Davé, E. Bilgili, “An Intensified Vibratory Milling Process for Enhancing the Breakage Kinetics during the Preparation of Drug Nanosuspensions”, AAPS PharmSciTech, 17(2), 2016
     
  20. R. Susarla, A. Afolabi, Darshan Patel, E. Bilgili, R. N. Davé, “Novel use of superdisintegrants as viscosity enhancing agents in biocompatible polymer films containing griseofulvin nanoparticles”, Powder Technology, 285:25–33, 2015
     
  21. M. Azad, A. Afolabi, A. Bhakay, J. Leonardi, R. Davé, E. Bilgili, “Enhanced physical stabilization of fenofibrate nanosuspensions via wet co-milling with a superdisintegrant and an adsorbing polymer”, European Journal of Pharmaceutics and Biopharmaceutics, 94:372-385, 2015
     
  22. L. J. Jallo, R. N. Davé, “Explaining Electrostatic Charging and Flow of Surface-Modified Acetaminophen Powders as a Function of Relative Humidity Through Surface Energetics”, Journal of Pharmaceutical Sciences, 104:2225–2232, 2015
     
  23. S. Krull, R. Susarla, A. Afolabi, M. Li, Y. Ying, Z. Iqbal, E. Bilgili, R. N. Davé, “Polymer strip films as a robust, surfactant-free platform for delivery of BCS Class II drug nanoparticles”, International Journal of Pharmaceutics, 489:45–57, 2015
     
  24. M. Capece, R. Davé, “Enhanced Physical Stability of Amorphous Drug Formulations via Dry Polymer Coating”, Journal of Pharmaceutical Sciences, 104:2076–2084, 2015
     
  25. S. M. Krull, M. Li, E. Bilgili, and R. N. Davé, “Polymer Strip Films for Delivery of Poorly Water-Soluble Drug”, American Pharmaceutical Review, Invited Contribution, 2015
     
  26. M. Li, Naveen Yaragudi, A. Afolabi, R. Davé, E. Bilgili, “Sub-100 nm drug particle suspensions via wet milling with low bead contamination through novel process intensification”, Chemical Engineering Science, 130:207-220, 2015
     
  27. M. Azad, C. Arteaga, B. Abdelmalek, R. Davé, E. Bilgili, “Spray drying of drug–swellable dispersant suspensions for preparation of fast-dissolving, high drug loaded, surfactant-free nanocomposites”, Drug Development and Industrial Pharmacy, 41(10):1617-1631, 2015
     
  28. M. Capece, J. Barrows, and R. N. Davé, “Controlled Release from Drug Microparticles via Solventless Dry-polymer Coating”, Journal of Pharmaceutical Sciences, 104:1340–1351, 2015
     
  29. M. Capece, R. N. Davé, E. Bilgili, “On the origin of non-linear breakage kinetics in dry milling processes”, Powder Technology, 272:189-203, 2015
     
  30. X. Deng, J. Scicolone, X. Han, R. N. Davé, “Discrete Element Method Simulation of a Conical Screen mill: A Continuous Dry Coating Device”, Chemical Engineering Science, 125:58–74, 2015
     
  31. Z. Huang, J. V. Scicolone, L. Gurumurthy, R. N. Davé, “Flow and Bulk Density Enhancements of Pharmaceutical Powders using a Conical Screen Mill: A Continuous Dry Coating Device”, Chemical Engineering Science, 125:209–224, 2015 
     
  32. C. Knieke, M. Azad, D. To, E. Bilgili, R. N. Davé, “Sub-100 micron Fast Dissolving Fluidized Bed Coated Nanocomposite Drug Powders”, Powder Technology, 271:49-60, 2015
     
  33. Z. Huang, J. V. Scicolone, X. Han, R. N. Davé, “Improved blend and tablet properties of fine pharmaceutical powders via dry particle coating”, International Journal of Pharmaceutics, 478(2):447-455, 2015
     
  34. M. A. Azad, C. Knieke, D. To, R. Davé, “Preparation of Concentrated Stable Fenofibrate Suspensions via Liquid Antisolvent Precipitation”, Drug Development and Industrial Pharmacy, 40(12):1693-1703, 2014
     
  35. A. Bhakay, M. Azad, E. Vizzotti, R. N. Davé, and E. Bilgili, “Enhanced recovery and dissolution of griseofulvin nanoparticles from surfactant-free nanocomposite microparticles incorporating wet-milled swellable dispersants”, Drug Development and Industrial Pharmacy, 40(11):1509–1522, 2014
     
  36. J. Zhang, Y. Ying, B. Pielecha-Safira, E. Bilgili, R. Ramachandran, R. Romañach, R. Davé, Z. Iqbal, “Raman spectroscopy for in-line and off-line quantification of poorly soluble drugs in strip films”, International Journal of Pharmaceutics, 475(1-2):428–437, 2014
     
  37. M. Capece, E. Bilgili, R. N. Davé, “Insight into First-order Breakage Kinetics Using a Particle-scale Breakage Rate Constant”, Chemical Engineering Science, 117:318-330, 2014
     
  38. M. Capece, R. N. Davé, “Solventless Polymer Coating of Microparticles”, Powder Technology, 261:118-132, 2014
     
  39. M. Capece, E. Bilgili, R. N. Davé, “Formulation of a Physically Motivated Breakage Rate Parameter for Dry Ball Milling via the Discrete Element Method”, AIChE Journal, 60(7):2404–2415, 2014
     
  40. M. A. Azad, A. Afolabi, N. Patel, R. Davé, E. Bilgili, “Preparation of Stable Colloidal Suspensions of Superdisintegrants via Wet Stirred Media Milling”, Particulogy, 14:76-82, 2014
     
  41. M. Capece, Z. Huang, D. To, M. Aloia, C. Muchira, R. N. Davé, A.B. Yu, “Prediction of Porosity from Particle Scale Interactions:  Surface Modification of Fine Cohesive Powders”, Powder Technology, 254:103–113, 2014
     
  42. A. Bhakay, M. Azad, E. Bilgili, R. N. Davé, “Redispersible fast dissolving nanocomposite microparticles of poorly water-soluble drugs”, International Journal of Pharmaceutics, 461(1-2):367-379, 2014
     
  43. C. Knieke, A. Rawtani, R. N. Davé, “Concentrated fenofibrate nanoparticle suspensions from melt emulsification for enhanced drug dissolution”, Chemical Engineering & Technology, 37(1):157-167, 2014
     
  44. R. Susarla, L. Sievens-Figueroa, A. Bhakay, Y. Shen, J. I. Jerez-Rozo, W. Engen, B. Khusid, E. Bilgili, R. J. Romañach, K. R. Morris, B. Michniak-Kohn, R. N. Davé, “Fast drying of biocompatible polymer films loaded with poorly water-soluble drug nano-particle via low temperature forced convection”, International Journal of Pharmaceutics, 455(1-2):93-103, 2013
     
  45. X. Deng, R. N. Davé, “Dynamic simulation of particle packing influenced by size, aspect ratio and surface energy”, Granular Matter, Special Issue, 15:401–415, 2013. DOI:10.1007/s10035-013-0413-0
     
  46. X. Han, L. Jallo, D. To, C. Ghoroi, R. Davé, “Passivation of high surface energy sites of milled ibuprofen crystals via dry coating”, Journal of Pharmaceutical Sciences, 102(7):1–15, 2013
     
  47. X. Deng, J. Scicolone, R. N. Davé, “Discrete element method simulation of cohesive particles mixing under magnetically assisted impaction”, Powder Technology, 243: 96-109, 2013. DOI:10.1016/j.powtec.2013.03.043
     
  48. C. Knieke, M. A. Azad, R. N. Davé, E. Bilgili, “A Study of the Physical Stability of Wet Media-Milled Fenofibrate Suspensions Using Dynamic Equilibrium Curves”, Chemical Engineering Research and Design, 91(7):1245-1258, 2013. DOI:10.1016/j.cherd.2013.02.008
     
  49. M. Capece, R. N. Davé, E. Bilgili, “Influence of Non-Linear Breakage Kinetics on the Attainment of Self-Similarity for Dry Milling Processes”, Chemical Engineering Science, 97:96-107, 2013.  DOI:10.1016/j.ces.2013.04.017
     
  50. J. Scicolone, D. Lepek, L. Louie and R. N. Davé, “Fluidization and Mixing of Nanoparticle Agglomerates Assisted via Magnetic Impaction”, Journal of Nanoparticle Research, 15:1434, 2013. DOI:10.1007/s11051-013-1434-7
     
  51. J. F. Gamble, R. N. Davé, S. Kiang, M. M. Leane, M. Tobyn, S. S.Y. Wang, “Investigating the applicability of inverse gas chromatography to binary powdered systems: An application of surface heterogeneity profiles to understanding preferential probe-surface interactions”, International Journal of Pharmaceutics, 445:39-46, 2013. DOI:10.1016/j.ijpharm.2013.01.061
     
  52. R. Davé, E. Bilgili, A. Cuitiño, L. Jallo, “Special Issue on Pharmaceutical Powders: Towards Developing Understanding of the Influence of Materials and Processes on Product Performance”, Powder Technology, An Editorial, 236:1-4, 2012. DOI:10.1016/j.powtec.2012.09.005
     
  53. R. B. Patel, J. Liu, J. V. Scicolone, S. Roy, S. Mitra, R. N. Davé, Z. Iqbal, “Formation of Stainless Steel-Carbon Nanotube Composites using a Scalable Chemical Infiltration Process”, Journal of Materials Research, 48(3):1387-1395, 2013. DOI:10.1007/s10853-012-6885-1
     
  54. X. Han, C. Ghoroi, R. Davé, “Dry coating of micronized API powders for improved dissolution of directly compacted tablets with high drug loading”, International Journal of Pharmaceutics, Special Issue: Mechanical Properties of Drug Tablets, 442:74-85, 2013. DOI:10.1016/j.ijpharm.2012.08.004
     
  55. C. Beck , L. Sievens-Figueroa, K. Gärtner, J. I. Jerez-Rozo, R. J. Romañach, E. Bilgili, R. N. Davé, “Effects of stabilizers on particle redispersion and dissolution from polymer strip films containing liquid antisolvent precipitated griseofulvin particles”, Powder Technology, Special Issue: Pharmaceutical Powders, 236:37-51, 2013. DOI:10.1016/j.powtec.2012.05.047
     
  56. A. Łuczak, L. J. Jallo, R. N. Davé, Z. Iqbal, “Polymorph Stabilization in Processed Acetaminophen Powders”, Powder Technology, Special Issue: Pharmaceutical Powders, 236:52-62, 2013. DOI:10.1016/j.powtec.2012.05.046
     
  57. C. Ghoroi, L. Gurumurthy, D. J. McDaniel, L. Jallo, R. N. Davé, “Multi-faceted characterization of flow, packing and fluidization properties of pharmaceutical powders to discern the influence of surface modification”, Powder Technology, Special Issue: Pharmaceutical Powders, 236:63-74, 2013. DOI:10.1016/j.powtec.2012.05.039 
     
  58. S. Dalvi, M. Azad, R. N. Davé, “Precipitation and Stabilization of Ultrafine Particles of Fenofibrate in Aqueous Suspensions by RESOLV”, Powder Technology, Special Issue: Pharmaceutical Powders, 236:75-84, 2013. DOI:10.1016/j.powtec.2012.05.038
     
  59. A. Bhakay, E. Bilgili, R. Davé, “Recovery of BCS Class II drugs during aqueous redispersion of core-shell type nanocomposite particles produced via fluidized bed coating”, Powder Technology”, Special Issue: Pharmaceutical Powders, 236:221-234, 2013. DOI:10.1016/j.powtec.2011.12.066
     
  60. C. Ghoroi, X. Han, D. To, L. Jallo, L. Gurumurthy, R. N. Davé, “Dispersion of ultrafine powders through surface modification or rapid expansion”, Chemical Engineering Science, Special Issue (Ed. F. Saito), 85:11-24, 2013. DOI:10.1016/j.ces.2012.02.038
     
  61. L. Sievens-Figueroa, N. Pandya, A. Bhakay, G. Keyvan, B. Michniak-Kohn, E. Bilgili, R. N. Davé, “Using USP I and USP IV for discriminating dissolution rates of nano and micro particle loaded pharmaceutical strip-films”,  AAPS PharmSciTech, 13(4):1473-1482, 2013. DOI:10.1208/s12249-012-9875-3
     
  62. M. Capece, R. Davé, E. Bilgili, “A Rational Function Approximation to the Effectiveness Factor for Multi-Particle Interactions in Dense-Phase Dry Milling”, Powder Technology, 230:67–76, 2012. DOI:10.1016/j.powtec.2012.06.054
     
  63. D. K. Balachandran, L. J. Jallo, R. Davé, S. P. Beaudoin, “Adhesion of Dry Nano-Coated Particles to Stainless Steel: A Physical Interpretation”, Powder Technology, 226:1-9, 2012. DOI:10.1016/j.powtec.2012.02.035
     
  64. W. Zhu, F. S. Romanski, S. V. Dalvi, R. N. Davé, M. S. Tomassone, “Atomistic Simulations of Aqueous Griseofulvin Crystals in the Presence of Individual and Multiple Additives”, Chemical Engineering Science, 73:218–230, 2012. DOI:10.1016/j.ces.2012.01.008
     
  65. A. Banerjee, R. N. Davé, “Robust Clustering”, Wiley Interdisciplinary Reviews: Data Mining and Knowledge Discovery, 2(1):29-59, 2012. DOI:10.1002/widm.49/abstract
     
  66. L. J. Jallo, C. Ghoroi, L. Gurumurthy, U. Patel, R. N. Davé, “Improvement of flow and bulk density of pharmaceutical powders using surface modification”, International Journal of Pharmaceutics, 423:213– 225, 2012. DOI:10.1016/j.ijpharm.2011.12
     
  67. L. Sievens-Figueroa, A. Bhakay, J. I. Jerez-Rozo, N. Pandya, R. Romanach, B. Michniak-Kohn, Z. Iqbal, E. Bilgili, R. N. Davé, “Preparation and characterization of hydroxypropyl methyl cellulose films containing stable BCS Class II drug nanoparticles for pharmaceutical applications”, International Journal of Pharmaceutics, 423(2):496–508, 2012. DOI:10.1016/j.ijpharm.2011.12.001
     
  68. M. Capece, E. Bilgili, R. Davé, “Emergence of falsified kinetics as a consequence of multi-particle interactions in dense-phase comminution processes”, Chemical Engineering Science, 66(22):5672-5683, 2011. DOI:10.1016/j.ces.2011.08.001
     
  69. M. P. Mullarney, L. E. Beach, R. N. Davé, B. A. Langdon, M. Polizzi, D. O. Blackwood, “Applying dry powder coatings to pharmaceutical powders using a comil for improving powder flow and bulk density”, Powder Technology, 212(3):397–402, 2011. DOI:10.1016/j.powtec.2011.06.008
     
  70. X. Han, C. Ghoroi, D. To; Y. Chen, R. N. Davé, "Simultaneous micronization and surface modification for improvement of flow and dissolution of drug particles”, International Journal of Pharmaceutics, 415(1-2):185–195, 2011. DOI:10.1016/j.ijpharm.2011.05.070
     
  71. D. To, R. N. Davé, S. Sundaresan, “Nano-particle Mixing through Rapid Expansion of High-Pressure and Supercritical Suspensions”, Journal of Nanoparticle Research, 13(9):4253-4266, 2011. DOI:10.1007/s11051-011-0369-0
     
  72. M. Capece, R. N. Davé, “Application of Fluidized Bed Film Coating for Membrane Encapsulation of Catalysts”, Powder Technology, 211(2-3):199-206, 2011. DOI:10.1016/j.powtec.2011.04.015
     
  73. A. Bhakay, M. Merwade, E. Bilgili, and R. N. Davé, “Novel Aspects of the Wet Media Milling for the Production of Microsuspensions and Nanosuspensions of Poorly Water-Soluble Drugs”, Drug Development and Industrial Pharmacy, 37(8):963-976, 2011. DOI:10.3109/03639045.2010.551775
     
  74. J. Scicolone, A. Mujumdar, S. Sundaresan, and R. N. Davé, “Environmentally Benign Dry Mechanical Mixing of Nano-particles using Magnetically Assisted Impaction Mixing Process”, Powder Technology, 209(1-3):138-146, 2011. DOI:10.1016/j.powtec.2011.02.021
     
  75. M. Capece, E. Bilgili, R. Davé, “Identification of the Breakage Rate and Distribution Parameters in a Non-linear Population Balance Model for Batch Milling”, Powder Technology, 208(1):195-204, 2011. DOI:10.1016/j.powtec.2010.12.019
     
  76. J. Carpinelli, H. Kimmel, L. Hirsch, L. Burr-Alexander, A. Narh, R. N. Davé, “Translating research experiences into classroom practice: An RET Project”, 11th ASEE Annual Conference and Exposition, 18pp, 2011
     
  77. L. J. Jallo, Y. Chen, J. Bowen, F. Etzler, and R. Davé, “Prediction of Inter-particle Adhesion Force from Surface Energy and Surface Roughness”, Journal of Adhesion Science and Technology, 25(4-5):367-384, 2011. DOI:10.1163/016942410X525623
     
  78. C. Beck, S. V. Dalvi, R. Davé, “Controlled Liquid Antisolvent Precipitation of Drug Particles using a Rapid Mixing Device”, Chemical Engineering Science, 65:5669–5675, 2010. DOI:10.1016/j.ces.2010.04.001
     
  79. L. J. Jallo, M. A. Schoenitz, E. L. Dreizin, R. N. Davé, and C. E. Johnson, “The effect of surface modification of aluminum powder on its flowability, combustion and reactivity”, Powder Technology, 204:63-70, 2010. DOI:10.1016/j.powtec.2010.07.017
     
  80. L. Beach, J. Ropero, A. Mujumdar, M. Alcalà, R. J. Romañach, R. N. Davé, “Near-infrared Spectroscopy for the In-line Characterization of Powder Voiding, Part II: Quantification of Enhanced Flow Properties of Surface Modified Active Pharmaceutical Ingredients”, Journal of Pharmaceutical Innovation, 5(1-2):2010. DOI:10.1007/s12247-010-9075-1
     
  81. Y. Chen, L. Jallo, M. A. S. Quintanilla, R. Davé, “Characterization of Particle and Bulk Level Cohesion Reduction of Surface Modified Fine Aluminum Powders”, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 361:66-80, 2010. DOI:10.1016/j.colsurfa.2010.03.015
     
  82. S. V. Dalvi, R. N. Davé, “Analysis of Nucleation Kinetics of Poorly Water Soluble Drugs in presence of Ultrasound and Hydroxypropyl Methyl Cellulose during Antisolvent Precipitation”, International Journal of Pharmaceutics, 387(1-2):172–179, 2010. DOI:10.1016/j.ijpharm.2009.12.026
     
  83. D. Lepek, J.M. Valverde, R. Pfeffer, A. Castellanos, R.N. Davé, “Enhanced Nanofluidization by Alternating Electric Fields”, AIChE Journal, Cover Article, 56(1):54-65, 2010. DOI:10.1002/aic.11954
     
  84. J. Ropero, L. Beach, M. Alcalà, R. Rentas, , R. N. R. Davé J. Romañach, “Near-infrared Spectroscopy for the In-line Characterization of Powder Voiding, Part I: Development of the Methodology”, Journal of Pharmaceutical Innovation, 4(4):187-197, 2009. DOI:10.1007/s12247-009-9069-z
     
  85. D. To, R. Davé, X. Yin, S. Sundaresan “Deagglomeration of nanoparticle aggregates via rapid expansion of supercritical or high-pressure suspensions”,AIChE Journal, 55(11):2807-2826, 2009. DOI:10.1002/aic.11887
     
  86. Q. Zhang, J. Yang, S. Teng, R. N. Davé, L. Zhu, P. Wang, MW. Young, C. G. Gogos, “In-situ, Simultaneous Milling and Coating of Particulates with Nano-particles”, Powder Technology, 196(3):292-297, 2009. DOI:10.1016/j.powtec.2009.08.011
     
  87. H. Kimmel, L. S. Hirsch, L. Simon, L. Burr-Alexander, R. N. Davé, “Implementing Concepts of Pharmaceutical Engineering into High School Science Classrooms”, Chemical Engineering Education, 43(3):187-193, 2009
     
  88. S. V. Dalvi and R. N. Davé, “Controlling particle size of a poorly water-soluble drug using ultrasound and stabilizers in antisolvent precipitation”,Industrial and Engineering Chemistry Research, 48(16):7581–7593, 2009. DOI:10.1021/ie900248f
     
  89. X. Jiang, M. A. Trunov, M. Schoenitz, R. N. Davé, E. L. Dreizin, “Mechanical Alloying and Reactive Milling in a High Energy Planetary Mill”, Journal of Alloys and Compounds, 478(1-2):10, 246-251, 2009. DOI:10.1016/j.jallcom.2008.12.021
     
  90. Y. Chen, M. A. S. Quintanilla, J. J. Yang M. Valverde and R. N. Davé, “Pull-off Force of Coated Fine Powders under Small Consolidation”, Physical Review E, 79(4):41-305, 2009. DOI:10.1103/PhysRevE.79.041305
     
  91. Y. Chen, J. Yang, R. N. Davé and R. Pfeffer, “Granulation of Cohesive Geldart Group C Powders in a Mini-Glatt Fluidized Bed by pre-coating with nanoparticles”, Powder Technology, 191(1-2):206–217, 2009. DOI:10.1016/j.powtec.2008.10.010
     
  92. G. P. Sanganwar, R. Gupta, A. Ermoline, J. V. Scicolone, R. N. Davé, “Environmentally Benign Nano-mixing by Sonication in high-pressure CO2”, Journal of Nanoparticle Research, 11(2): 405, 2009. DOI:10.1007/s11051-008-9394-z
     
  93. Y. Chen, J. Yang, A. Mujumdar, R. N. Davé, “Fluidized Bed Film Coating of Cohesive Geldart Group C Powders”, Powder Technology, Anchor189:466–480, 2009. DOI:10.1016/j.powtec.2008.08.002
     
  94. M.A.S. Quintanilla, J.M. Valverde, A. Castellanos, , R. Pfeffer, and R. N. Davé, “Nano fluidization as affected by vibration and electrostatic fields”, Chemical Engineering Science, 63(22):5559-5569, 2008. DOI:10.1016/j.ces.2008.08.012
     
  95. J. Quevedo, G. Patel, R. R. Pfeffer Davé, “Agglomerates and granules of nanoparticles as filter media for submicron particles”, Powder Technology 183(3):480-500, 2008. DOI:10.1016/j.powtec.2008.01.020
     
  96. Y. Chen, J. Yang, R. N. Davé and R. Pfeffer, “Fluidization of Coated Group C Powders”, AIChE Journal, 54(1):104-121, 2008. DOI:10.1002/aic.11368/abstract
     
  97. J. M. Valverde, M. A. S. Quintanilla, A. Catellanos, D. Lepek, R. N. R. Davé Pfeffer, “Fluidization of fine and ultrafine particles using nitrogen and neon as fluidizing gases”, AIChE Journal, 54(1):86-103, 2008. DOI:10.1002/aic.11329/abstract
     
  98. A. Gokhale, B. Khusid, R. N. R. Davé Pfeffer, “Effect of the Solvent Strength on the Formation of Submicronmeter Polymer Particles in Supercritical Microjets”, Journal of Supercritical fluids, 43(2):341-356, 2007
     
  99. A. Banerjee, M. Misra, D. Pai, L-Y. Shih, R. Woodley, X–J. Lu, A.R. Srinivasan, W. K. Olson, R. N. Davé, and C. A. Venanzi, “Feature Extraction Using Molecular Planes for Fuzzy Relational Clustering of a Flexible Dopamine Reuptake Inhibitor”, Journal of Chemical Information and Modeling, 47:2216-2227, 2007
     
  100. S. S. Dukhin, Y. Shen, R. R. Davé Pfeffer; “Development in modeling submicron particle formation in two phases flow of solvent-supercritical antisolvent emulsion”, Advances In Colloid And Interface Science, (134-135), 72-88, 2007
     
  101. R. Barrow, J. Yang, R. R. Davé Pfeffer, “Dry-mixing of sub-micron B and BaCrO4 particles for use in a time delay composition ”, SAFE Journal, 35(1):7-13, 2007
     
  102. J. A. Quevedo, J. Flesch, R. R. Pfeffer Davé, “Evaluation of Assisting Methods on Fluidization of Hydrophilic Nanoagglomerates by Monitoring Moisture in the Gas Phase”, Chemical Engineering Science, 62(9):2608-2622, 2007
     
  103. J. Quevedo, H. Nakamura, Y. Shen, R. N. R. Davé Pfeffer, S. Watano, “Fluidization of Nanoparticles in a Rotating Fluidized Bed”, AIChE Journal, 52(7):2401-2412, 2006
     
  104. Y. Wang, Y-P. Wang, J. Yang, R. R. Pfeffer N. Davé, B. Michniak, “Application of Supercritical Antisolvent Process for Sustained Drug Delivery System”, Powder Technology, 164(2):94-102, 2006
     
  105. W. Chen, M. Schoenitz, T. S. Ward, R. N. Davé, E. L. Dreizin, “Numerical Simulation of Mechanical Alloying in a Shaker Mill by Discrete Element Method”, KONA, 23:152-162, 2005
     
  106. J. Yang, A. Sliva, A. Banerjee, R. N. R. Davé Pfeffer, “Dry particle coating for improving the flowability of cohesive powders”, Powder Technology, Special Issue in Memory of Prof. Molerus, 158(1-3):21-33, 2005
     
  107. A. Banerjee, R. N. Davé, “The fuzzy mega-cluster: Robustifying FCM by scaling down memberships”, (2005) Lecture Notes in Artificial Intelligence (Subseries of Lecture Notes in Computer Science), 3613 PART I, pp. 444-453, 2005
     
  108. B. Yue, J. Yang, C-Y. Huang, R. Davé, R. Pfeffer, “Synthesis of macroporous PMMA/silica nanocomposite monoliths in supercritical carbon dioxide”, Macromolecular Rapid Communications, 26(17):1406-1411, 2005
     
  109. Q. Yu, R. N. Davé, C. Zhu, J. A. Quevedo, R. Pfeffer “Enhanced fluidization of nanoparticles in an oscillating magnetic field”, AIChE Journal, 51(7):1971-1979, 2005
     
  110. S. S. Dukhin, Y. Shen, R. Davé, R. Pfeffer, “Droplet mass transfer, intradroplet nucleation and submicron particle production in two-phase flow of solvent-supercritical antisolvent emulsion”, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 261(1-3):163-176, 2005
     
  111. S. Dukhin, C. Zhu, R. N. Davé, Q. Yu, “Hydrodynamic fragmentation of nanoparticle aggregates at orthokinetic coagulation”, Advances in Colloid and Interface Science, (114-115):119-131, 2005
     
  112. M. Misra, A. Banerjee, R. N. Davé, C. A. Venanzi, “Novel feature extraction technique for fuzzy relational clustering of a flexible dopamine reuptake inhibitor”, Journal of Chemical Information and Modeling, 45(3):610-623, 2005
     
  113. C. Zhu, Q. Yu, R. N. Davé, R. Pfeffer Gas fluidization characteristics of nanoparticle agglomerates,  AIChE Journal, 51(2):426-439, 2005
     
  114. Y. Wang, R. Pfeffer, R. N. Davé, R. Enick, “Polymer encapsulation of fine particles by a supercritical antisolvent process”, AIChE Journal, 51(2):440-455, 2005
     
  115. T. S. Ward, W. Chen, M. Schoenitz, R. N. Davé, E. L. Dreizin, “A Study of Mechanical Alloying Processes using Reactive Milling and Discrete Element Modeling”, Acta Materialia, 53(10):2909-2918, 2005
     
  116. B. Yue, J. Yang, Y. Wang, C-Y. Huang, R. Davé, R. Pfeffer, “Particle encapsulation with polymers via in situ polymerization in supercritical CO2”, Powder Technology, 146(1-2):32-45, 2004
     
  117. W. Chen, R. N. Davé, R. Pfeffer, O. Walton, “Numerical simulation of Mechanofusion system”,  Powder Technology, 146(1-2):121-136, 2004
     
  118. C. H. Nam, R. Pfeffer, R. N. Davé, S. Sundaresan, “Aerated vibrofluidization of silica nanoparticles”, AIChE Journal, 50(8):1776-1785, 2004
     
  119. S. Watano, H. Nakamura, K. Hamada, Y. Wakamatsu, Y. Tanabe, R. N. Davé, R. Pfeffer, “Fine particle coating by a novel rotating fluidized bed coater”, Powder Technology, 141(3):172-176, 2004
     
  120. C. Zhu, G. Liu, Q. Yu, R. Pfeffer, R. N. Davé, C. H. Nam, “Sound assisted fluidization of nanoparticle agglomerates”, Powder Technology, 141(1-2):119-123, 2004
     
  121. S. S. Dukhin, J. Yang, R. N. Davé, R. Pfeffer, “Deactivated sintering by particle coating: The significance of static and dynamic surface phenomena”, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 235(3):83-99, 2004
     
  122. A. Mujumdar, D. Wei, R. N. Davé, R. Pfeffer, C-Y. Wu, “Improvement of humidity resistance of magnesium powder using dry particle coating”, Powder Technology, 140(1-2):86-97, 2004
     
  123. Y. Wang, R. N. Davé, R. Pfeffer, “Polymer coating/encapsulation of nanoparticles using a supercritical anti-solvent process”, Journal of Supercritical Fluids, 28(1):85-99, 2004
     
  124. S. S. Dukhin, C. Zhu, R. Davé, R. Pfeffer, J. J. Luo, F. Chávez, Y. Shen, “Dynamic interfacial tension near critical point of a solvent-antisolvent mixture and laminar jet stabilization”, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 229(1-3):181-199, 2004
     
  125. M. Malik, A. Mujumdar, R. Davé, “Numerically simulated flow characteristics of particulate beds in oscillating sectorial containers”, Powder Technology, 133(1-3):91-105, 2003
     
  126. F. Chávez, P. G. Debenedetti, J. J. Luo, R. N. Davé, R. Pfeffer, “Estimation of the characteristic time scales in the supercritical antisolvent process”, Industrial and Engineering Chemistry Research, 42(13):3156-3162, 2003
     
  127. S. Watano, Y. Imada, K. Hamada, Y. Wakamatsu, Y. Tanabe, R. N. Davé, R. Pfeffer, “Microgranulation of fine powders by a novel rotating fluidized bed granulator”, Powder Technology, 131(2-3):250-255, 2003
     
  128. M. R. Mohan, R. N. Davé, R. Pfeffer, “Promotion of deactivated sintering by dry-particle coating”, AIChE Journal, 49(3):604-618, 2003
     
  129. J. Yang, Y. Wang, R. N. Davé, R. Pfeffer, “Mixing of nano-particles by rapid expansion of high-pressure suspensions”, Advanced Powder Technology, 14(4):471-493, 2003
     
  130. R. Davé, W. Chen, A. Mujumdar, W. Wang, R. Pfeffer, “Numerical simulation of dry particle coating processes by the discrete element method”, Advanced Powder Technology, 14(4):449-470, 2003
     
  131. D. Wei, R. Davé, R. Pfeffer, “Mixing and characterization of nanosized powders: An assessment of different techniques”, Invited Review Contribution, Journal of Nanoparticle Research, 4(1-2):21-41, 2003
     
  132. R. N. Davé, S. Sen, “Robust fuzzy clustering of relational data”, IEEE Transactions on Fuzzy Systems, 10(6):713-727, 2002
     
  133. Y. Wang, R. Davé, R. Pfeffer, M. Sauceau, J. J. Letourneau, J. Fages, “Extraction and precipitation particle coating using supercritical CO2”, Powder Technology, 127(1):32-44, 2002
     
  134. P. Singh, T. K. S. Solanky, R. Mudryy, R. Pfeffer, R. Davé, “Estimation of coating time in the magnetically assisted impaction coating process”, Powder Technology, 121(2-3):159-167, 2002
     
  135. R. Pfeffer, R. N. Davé, D. Wei, M. Ramlakhan, “Synthesis of engineered particulates with tailored properties using dry particle coating” Powder Technology, 117(1-2):40-67, 2001
     
  136. S. Watano, Y. Imada, K. Miyanami, C. Y. Wu, R. N. Davé, R. Pfeffer, T. Yoshida, “Surface modification of food fiber by dry particle coating”, Journal of Chemical Engineering of Japan, 33(6):848-854, 2000
     
  137. M. Ramlakhan, Wu, C.Y., S. Watano, R. N. Davé, R. Pfeffer, “Dry particle coating using magnetically assisted impaction coating: Modification of surface properties and optimization of system and operating parameters”, Powder Technology, 112(1-2):137-148, 2000
  138. R. N. Davé, C. Y. Wu, B. Chaudhuri, S. Watano, “Magnetically mediated flow enhancement for controlled powder discharge of cohesive powders”, Powder Technology, 112(1-2):111-125, 2000
     
  139. S. Watano, R. Pfeffer, R. N. Davé, W. Dunphy, “Dry Particle Coating by a Newly Developed Rotating Fluidized Bed Coater”, AIChE Symposium, Advanced Technology for Fluid-Particle System, 321(95):112-116, 1999
     
  140. R. N. Davé, A. Rosato, I. S. Fischer, “Non-Intrusive Particle Tracking System for Particulate Flows and Vibrated Granular Beds”, Particulate Science and Technology: An International Journal, 17(1-2):125-139, 1999
     
  141. C. Y. Wu, S. Watano, R. N. Davé, “Magnetically Enhanced Powder Discharge from Storage under High Consolidation”, Powder Handling and Processing, 10(4):357-361, 1998
     
  142. R. N. Davé, B. G. Bukiet, “Non-Intrusive Rigid Body Tracking Technique for Dry Particulate Flows, Part I: Theoretical Aspects”, Review of Scientific Instruments, 69(10):3598-3505, 1998
     
  143. R. N. Davé, J. Volcy, J. Agarwal, V. Gupta, “Non-Intrusive Rigid Body Tracking Technique for Dry Particulate Flows, Part II: Practical Aspects”,  Review of Scientific Instruments, 69(10):3506-3513, 1998
     
  144. R. N. Davé, I. S. Fischer, J. Luke, R. Pfeffer, A. D. Rosato, “Particle Technology Concentration at NJIT: An NSF-CRCD Program”, Chemical Engineering Education, 32(2):102-107, 1998
     
  145. L. Labous, A. D. Rosato, R. N. Davé, “Measurements of Collisional Properties of Spheres Using High-speed Video Analysis”, Physical Review E, 56(5):5717-5725, 1997
     
  146. L. Vanel, A. D. Rosato, R. N. Davé, “Rise Regimes of a Large Sphere in Vibrated Bulk Solids”, Physical Review Letters, 78(7):1255-1258, 1997
     
  147. R. N. Davé, R. Krishnapurum, “Robust Clustering Methods: A Unified View”, IEEE Trans. Fuzzy Systems, 5(2):270-293, 1997
     
  148. R. N. Davé, “Validating Fuzzy Partitions Obtained through C-Shells Clustering”, Pattern Recognition Letters, 17(6):613-623, 1996
     
  149. J. Kim, R. Krishnapurum, R. N. Davé, “Application of the Least Trimmed Squares Technique to Prototype-Based Clustering”, Pattern Recognition Letters, 17(6):633-641, 1996
     
  150. R. N. Davé, A. D. Rosato, K. Bhaswan, “Characterization of clustering microstructure in highly inelastic low density uniform granular shear flows”,  Mechanics Research Communications, 22(4): 335-342, 1995
     
  151. R. N. Davé, T. Fu, “Robust Shape Detection Using Fuzzy Clustering: Practical Applications”, Fuzzy Sets and Systems, 65:161-185, 1994
     
  152. R. N. Davé, “Generalized Fuzzy c-Shells Clustering and Detection of Circular and Elliptical Boundaries”, Pattern Recognition, 25(7):713-721, 1992
     
  153. R. N. Davé, K. Bhaswan, “Adaptive Fuzzy c-Shells Clustering and Detection of Ellipses”, IEEE T. on Neural Networks, 3(5):643-662, 1992
     
  154. R. N. Davé, “Characterization and Detection of Noise in Clustering”, Pattern Recognition Letters, 12(11):657-664, 1991
     
  155. R. N. Davé, “Effect of the Circulation Number on the Stratification Coefficient for Solar heating Systems”, ASME Journal of Solar Energy Engineering, 113(4):250-256, 1991
     
  156. R. N. Davé, “Fuzzy Shell-Clustering and Applications to Circle Detection in Digital Images”, International Journal of General Systems, 16(4):343-355, 1990
     
  157. W. F. Phillips, R. N. Davé, “Effects of Stratification on the Performance of Liquid-Based Solar Heating Systems”, Solar Energy, 29(2):111-120, 1982