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Department of Chemical Biological and Pharmaceutical Engineering

Simon, Laurent

Contact Info
Title: Associate Professor
Email: laurent.simon@njit.edu
Office: 361 Tiernan
Phone: 973-596-5263
Dept: Otto H. York Chemical Engineering
Webpage:

Affiliations

  • American Institute of Chemical Engineers (AIChE)
  • International Society of Pharmaceutical Engineering (ISPE)
  • Parenteral Drug Association (PDA)
  • Minority Academic Committee (MAC)
  • Food, Pharmaceutical & Bioengineering Division of AIChE (FP&BE)
  • Separation Division of AIChE (SEP)
  • American Society for Engineering Education (ASEE)
  • National Organization of Black Chemists and Chemical Engineers (NOBCCHE)

Education

  • Colorado State University, PhD 2001
  • Colorado State University, MS 1998
  • New Jersey Institute of Technology, BS 1996

Awards and Honors

  • Recipient of the 2006-2007 Excellence in Teaching Award: Upper Division Undergraduate Instruction.  
  • Recipient of AICHE Student Chapter Appreciation Award in recognition of contributing to the NJIT Student Chapter, December, 2004-2006.  
  • Certificate of Appreciation from the American Institute of Chemical Engineers Minority Affairs Committee for providing support for and serving as a reviewer for the Minority Affairs Committee Scholarship Program, November, 2004.  
  • Poster Paper Award for work on beta-glucosidase purification using aqueous two-phase systems at the AIChE Annual meeting, Austin, TX, Nov 7-12, 2004. Soniya Patel was the recipient of the Award.  
  • Certificate of Appreciation from the New Jersey Chemistry Olympics Committee for generous support in judging competition, 2003-2007.  
  • Appreciation Award for outstanding contribution to Ronald E. McNair Post-Baccalaureate Achievement and University Research Experience Programs at the New Jersey Institute of Technology, 2003, 2004 & 2007.  
  • Appreciation Award in recognition of valuable contributions to McKinley Elementary School’s 2nd Annual Science Fair, March, 2004.  
  • Session Best Paper Award at the 2002 American Control Conference, Anchorage, AK, May 8-10.  
  • Award from the First Annual Rowan Boot Camp for Entrepreneurship for the "Most Innovative/Imaginative" project consisting of the development of a diabetic testing and treatment device. The Boot Camp, conducted through the Center for Innovation and Entrepreneurship at Rowan University, was funded, in part, by The Coleman Foundation & Inc - The Magazine for Growing Companies, October, 2002.

Courses I Teach

PROCESS DYNAMICS AND CONTROL
RESEARCH & INDEP STUDY
RESEARCH & INDEP STUDY
CHEM PROC DYNAMC & CNTRL
INDEPENDENT STUDY I
INDEPENDENT STUDY II
PRE-DOCTORAL RESEARCH
MASTERS THESIS
MASTERS THESIS
DOCT DISSERTATION & RES
DOCT DISSERTATION & RES
DOCT DISSERTATION & RES
DOCT DISSERTATION & RES
DOCT DISSERTATION & RES
DISSERTATION & RES
PRE-DOCTORAL RESEARCH
MASTER'S THESIS
MASTER'S THESIS

Courses Taught

PHEN 612  -- SPRING 2008

PHEN 501 -- FALL 2008


Refereed Journals

Simon, L. (2007), Repeated applications of a transdermal patch: analytical solution and optimal control of the delivery rate, Mathematical Biosciences, in press.

Simon, L. (2007), Analysis of heat-aided membrane-controlled drug release from a process control perspective, International Journal of Heat and Mass Transfer, 50, 2425-2433.Goyal, A. Mandapuram, S., Michniak, B. and Simon, L. (2006), Application of orthogonal collocation and regression techniques for recovering parameters of a two-pathway transdermal drug-delivery model, Computers & Chemical Engineering, 31, 107-120.

Gautam, S. and Simon, L. (2006), Prediction of equilibrium phase compositions and ß-glucosidase partition coefficient in aqueous two-phase systems, Chemical Engineering Communications, 194, 117-128.

Gautam, S. and Simon, L. (2006), Partitioning of ß-glucosidase from Trichoderma reesei in poly(ethylene glycol) and potassium phosphate aqueous two-phase systems: Influence of pH and temperature, Biochemical Engineering Journal, 30, 104-108.

Simon, L., Weltner, A.W., Wang, Y. and Michniak, B. (2006), A parametric study of iontophoretic transdermal drug-delivery systems, Journal of Membrane Science, 278, 124-132. Simon, L. and Loney, N.W. (2005), An analytical solution for percutaneous drug absorption: Application and removal of the vehicle, Mathematical Biosciences, 197, 119-139.

Fernandes, M., Simon, L. and Loney, N.W. (2005), Mathematical modeling of drug delivery systems: analysis and applications, Journal of Membrane Science, 256, 184-192. Loney, N.W., Huang, C. R. and Simon, L. (2005), Mathematical model of a counter current flow multi-fiber dialyzer, World Journal of Microbiology and Biotechnology, 21, 791-796. Simon, L. and Fernandes, M. (2004), Neural network-based prediction and optimization of estradiol release from ethylene-vinyl acetate membranes, Computers & Chemical Engineering, 28, 2407-2419. Simon, L. and Gautam, S. (2004), Modeling continuous aqueous two-phase systems for control purposes, Journal of Chromatography A., 1043, 135-147. Simon, L. (2005), Observing biomass concentration in a fixed-bed bioreactor, Chemical Engineering Communications, 192, 272-285. Karim, M.N., Hodge, D. and Simon, L. (2003), Data-based modeling and analysis of bioprocesses: some real experiences, Biotechnology Progress, 19,1591-1605. Simon, L. and Loney, N.W. (2003), Mathematical modeling and process control of distributed parameter systems, Chemical Engineering Education, 37,126-131. Loney, N.W., Simon, L. and Gao, L. (2003), Trends in the applications of neural networks in chemical process modeling, Proceedings of the IndianNational Science Academy Part A (Physical Sciences), 69, 285-299. Simon, L. and Karim, M.N (2002), Control of starvation-induced apoptosis in CHO cell Cultures, Biotechnology and Bioengineering, 78, 645-657. Simon, L. and Karim, M.N. (2001), Identification and control of dissolved oxygen in hybridoma cell culture in a shear sensitive environment, Biotechnology Progress, 17, 634-642. Simon, L. and Karim, M.N. (2001), Probabilistic Neural Networks using Bayesian decision strategies and a modified Gompertz model for growth phase classification in the batch culture of Bacillus subtilis, Biochemical Engineering Journal, 7, 41-48. Simon, L., Karim, M.N., and Schreweis, A. (1998), Prediction and classification of different phases in a fermentation using Neural Networks, Biotechnology Techniques, 12, 301-304. Simon, L. and Loney, N.W. (1996), An analytical solution for the concentration profile of a sublation process, Separation Science and Technology, 31,1019-1024.  

Book Chapters

Eikens, B., Karim, M. N. and Simon, L. (2001). Combining Neural Networks and first principle models for bioprocess modeling. In: Application of neural networks and other learning technologies in process engineering (I.M. Mujtaba and M.A. Hussain, Eds.). Imperial College Press. Eikens, B., Karim, M. N. and Simon, L. (2001). Process identification with self-organizing networks. In: Application of neural networks and other learning technologies in process engineering (I.M. Mujtaba and M.A. Hussain, Eds.). Imperial College Press.  

Selected Conference Papers

Simon, L., Armenante, P.M., Dave, R.N. (2007), Camp Pharma: A novel initiative to generate a pipeline of diverse student talents in pharmaceutical manufacturing, Spring 2007 ASEE Mid-Adtantic Section Conference, New Jersey Institute of Technology, Newark, NJ, April 11. Aly, Y. and Simon, L. (2007), Dosage administration using dynamic optimization techniques, Third Annual Provost´s Student Research Showcase, New Jersey Institute of Technology, Newark, NJ, April 11. Simon, L., Dave, R.N. and Armenante, P.M. (2007), Pharmaceutical Engineering: Education, research and collaboration opportunities for High School science teachers, JETS TEAMS Competition, Newark, NJ, March 12. Simon, L. (2006), Analysis of heat-Aided membrane-controlled drug release, AIChE Annual Meeting, San Francisco, CA, Nov 12-17, Ref. Number: 439h. Simon, L. (2006), Linear mixed-effects models in the MathematicaÒ environment, AIChE Annual Meeting, San Francisco, CA, Nov 12-17, Ref. Number: 457n. Simon, L. (2006), Data-driven and mechanistic models for transdermal absorption of chemicals, Wright-Patterson Air Force Base, Dayton, OH, July 12.

Goyal, A., Simon, L. and Iqbal, Z. (2005), Kinetic investigations of Co disproportionation on Co-Mo/Mgo bimetallic catalyst for single wall carbon nanotubes production, AIChE Annual meeting, Cincinnati, OH, Oct 30-Nov 4, Ref. Number: 331g. Simon, L. (2005), Aqueous two-phase extraction – a case study in process analysis and control, AIChE Annual meeting, Cincinnati, OH, Oct 30-Nov 4, Ref. Number: 237e. Simon, L. (2005), Mathematical analysis of non-conventional drug-delivery systems: iontophoretic and heat-aided transdermal patches, Laboratory for Drug Delivery & Industrial Membership Program, NJ Center for Biomaterials, Life Sciences Building Rutgers-The State University of New Jersey, Piscataway, NJ. Simon, L, Fernandes, M. and Loney, N.W. (2005), The use of mathematical modeling and simulation tools to study transdermal drug delivery systems, IEEE 31st Annual Northeast Bioengineering Conference, Hoboken, NJ, April 2-3. Loney, N.W., Huang, C. R. and Simon, L. (2005), Mathematical model of a multi- fibule counter current membrane separation device, 7th World Congress of Chemical Engineering, Glasgow, Scotland, United Kingdom, July 10-14. Simon, L. (2004), On the mathematical modeling of transdermal drug delivery system, The 7th New Jersey Symposium on Biomaterials Science - Challenges and Opportunities for the Biomaterials Scientist, New Brunswick, NJ, Oct 21-22. Simon, L. (2004), A project in mathematical modeling and testing of drug delivery systems, AIChE Annual meeting, Austin, TX, Nov 7-12, Ref. Number: 306f. Simon, L. and Loney, N.W. (2004), An analytical solution for a percutaneous absorption model: Application and removal of the vehicle, AIChE Annual meeting, Austin, TX, Nov 7-12, Ref. Number: 433c. Patel, S. and Simon, L. (2004), Purification of beta-glucosidase by aqueous two-phase partitioning, AIChE Annual meeting, Austin, TX, Nov 7-12. Gautam, S. and Simon, L. (2004), Purification of beta-glucosidase from Trichoderma Reesei by sequential precipitation with reversible soluble-insoluble polymers and aqueous two-phase systems, AIChE Annual meeting, Austin, TX, Nov 7-12, Ref. Number: 233e. Simon, L. (2004), An extended Kalman filter for biomass concentration estimation in a fixed-bed bioreactor, Southeastern Europe, USA, Japan and European Community Workshop on Research and Education in Control and Signal Processing, REDISCOVER, 2004, June 14-16, 2004, Hotel Croatia, Cavtat, Croatia. Weltner, A. and Simon, L. (2004), Characterizing transdermal drug delivery through mathematical modeling, Laboratory for Drug Delivery, New Jersey Center for Biomaterials, Newark, NJ. Loney, N.W. and Simon, L. (2004), Mathematical model of a counter current multi-fibule membrane mass exchanger, Graduate Research Poster Session, Guttenberg Information Technologies Center Building, New Jersey Institute of Technology, Newark, NJ. Simon, L. and Loney, N.W. (2004), A closed-form solution for percutaneous drug absorption: application and removal of the vehicle, Graduate Research Poster Session, Guttenberg Information Technologies Center Building, New Jersey Institute of Technology, Newark, NJ. Gautam, S. and Simon, L. (2004), Optimization of beta-glucosidase purification in aqueous two-phase systems, Graduate Research Poster Session, Guttenberg Information Technologies Center Building, New Jersey Institute of Technology, Newark, NJ. Patel, S. and Simon, L. (2004), Purification of beta-glucosidase, Fifth Annual Undergraduate research Symposium, Ronald E. McNair Post-Baccalaureate Achievement and University Research Experience Programs, New Jersey Institute of Technology, Newark, NJ. Simon, L. (2004), In search of a unified framework for drug delivery data analysis and interpretation for the 21st century, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ. Simon, L. (2003), On the use of Artificial Neural Networks to improve controlled release technologies, Laboratory for Drug Delivery, New Jersey Center for Biomaterials, Newark, NJ. Simon, L. (2003), An analytical solution for percutaneous drug absorption: application and removal of the vehicle, Fall 2003 Applied Mathematics Colloquium Series, New Jersey Institute of Technology, Newark, NJ. Simon, L. (2003), Teaching control of linear distributed systems to undergraduate chemical engineering students, AIChE Annual meeting, San Francisco, CA, Nov 16-21, Ref. Number: 346d. Gautam, S. and Simon, L. (2003), Optimization of sequential purification of beta-glucosidase by artificial neural networks, AIChE Annual meeting, San Francisco, CA, Nov 16-21, Ref. Number: 313e. Simon, L. and Loney, N.W. (2003), An analytical solution for percutaneous drug absorption, IEEE 29th Annual Northeast Bioengineering Conference, Newark, NJ. Simon, L. (2002), Case studies investigating the applications of neural networks to fermentation processes and predictions of O-glycosylation sites, Cornell University, Ithaca, NY. Simon, L. (2002), Observing biomass concentration profiles in a fixed-bed bioreactor, AIChE Annual meeting, Indianapolis, IN, Nov 3-8, Ref. Number: 318j. Gautam, S. and Simon, L. (2002), Artificial neural networks for the prediction of recombinant tissue-type plasminogen activator partition coefficients, AIChE Annual meeting, Indianapolis, IN, Nov 3-8, Ref. Number: 245f. Simon, L. and Gautam, S. (2002), Modeling continuous aqueous two-phase systems for control purposes, AIChE Annual meeting, Indianapolis, IN, Nov 3-8, Ref. Number: 112c. Simon, L. (2002), A Mathematica approach to solving distributed parameter systems via orthogonal collocations, 2002 ASEE Summer School, Boulder, CO, July 27- August 2. Simon, L. and Karim, M.N. (2002), Modeling and control of amino acid starvation induced apoptosis in CHO cell cultures, 2002 American Control Conference, Anchorage, AK, May 8-10, Ref Number: ACC02-INV4201. Simon, L. and Karim, M.N. (2001), Modeling and understanding of starvation-induced apoptosis in CHO cells, AIChE Annual meeting, Reno, NV, Nov 4-9, Ref. Number: 302g.