|Office:||Room No. 387, Tierman Hall|
|Dept:||Chemical Biological and Pharmaceutical Engineering|
Sagnik Basuray, PhD, completed his doctoral studies from the University of Notre Dame in the department of Chemical and Bio-Molecular Engineering in 2011, where he won the best thesis award. Since 2012, he was working as a postdoctoral fellow in the department of Electrical and Computer Engineering, University of Missouri, at the Center for Micro/Nano Systems and Nanotechnology, in the area of materials science, nanotechnology and optics. Prior to his stint at Missouri, he was working as a Research Scientist at 454 Life Sciences, a Roche Company, building the next generation semi-conductor based sequencing platform.
At Notre Dame he worked extensively in nanofluidics, microfluidics with core competency in biomedical diagnostics to research interfacial electro-kinetic properties like dielectrophoresis. He designed robust, cost-effective Point-of-Care devices with electrochemical sensors as an alternative to real time PCR and DNA sensing. The sensor work has been licensed and developed by F Cubed LLC. and is now in clinical trials. His research was highlighted during the 2010 Michigan-Notre Dame football game at halftime as an ad to showcase the research activities at the University of Notre Dame. During his postdoctoral stint, he has developed top-down fabrication protocols (soft lithography) to fabricate hierarchical nano-ordered plasmonic/photonic structures which show extra-ordinary electro-magnetic field enhancement. These were used to investigate single biological molecules like DNA, RNA, FRET pairs and to develop multi spatial/temporal techniques (Raman, Fluorescence) from a single platform. Sagnik has always worked closely with groups from biochemistry, biology, biological engineering across many collaborative and interdisciplinary research projects.
- Indian Institute of Technology (IIT), Bombay, India, B.Tech., 2002
- University of Notre Dame, Indiana, US, PhD, 2011
- 2012-2014 – Post-doctoral research fellow, University of Missouri
- 2011-2012 – Research Scientist, 454 Life Sciences, a Roche company, Connecticut
Awards and Honors
- 2011 Eli J. and Helen Shaheen Graduate School Awards winner (award for top graduating doctoral degree recipient in the Graduate School of Engineering in the University of Notre Dame).
- Fellowships for successive years 2006-2007, 2007-2008, from the Center for Applied Mathematics (CAM), University of Notre Dame, Indiana.
Our research efforts are to establish a synergy between novel nanostructures, optics (plasmonics and photonics), biology and electro-kinetics (microfluidics and nanofluidics) and integrate them to develop transformative and disruptive new technologies using cost-effective tools (3D printing). This will be instrumental in the development of fundamental understanding of interfaces and surface physics arising out of the interaction of metallic/dielectric atoms with biological molecules in an energy landscape.
- We are developing a new, cost-effective soft lithographic technique adaptable to 3D printers for microfluidic and nanofluidic architecture. Successive iterations will introduce hierarchical nano-ordered plasmonic-photonic metallic/dielectric surface topology for optical/Raman enhancement across a broad wavelength spectrum.
- Using the new surface DNA separation technique build upon surface entropic traps and electro-kinetic phenomena like dielectrophoresis (DEP), we will sequester, transport and thereby, isolate and/or concentrate species of interest. The goal is to fabricate a passive microfluidic MEMS device to isolate, concentrate and collect sweat for downstream measurement using the chromatographic surface DNA separation for measurement of Cystic Fibrosis.
- We are envisioning a new class of devices with liquid-liquid interfaces instead of solid-liquid interface for next generation of modular sensors (for point-of-care diagnostics) that will use interfacial phenomenon, surface energy landscape, electro-kinetics, electro-magnetic field enhancement for identification and measurement of biological molecules of interest.
- S. Gangopadhyay, V. Korampally, S. Basuray, K. Bhatnagar, A. Pathak, A. Ghosh, D. E. Menke, C. J. Mathai, P. V. Cornish, K. Gangopadhyay, “Nano-gap Grating Devices with Enhanced Optical Property and Fabrications thereof”, U.S Application No: 14/081353.
- C. T. A. Wong, G. C. Ferreri, S. Basuray, A. Bappal, S. G. Shenoy, X. V. Gomes, “System and Method for Operation of ISFET Arrays using pH Insert Reference Sensors”, Application No: 13/970167
- H. -C. Chang, J. Gordon, S. Senapati, Z. Gagnon and S. Basuray, Microfluidic Platforms for Multi-Target Detection, Application No: 12/246987 (Licensed to F Cube and receiving royalty payments since 2009).
- P. Musenheim, S. Basuray, S. Senapati, G. Yossifon and H. –C. Chang, Microchamber Electrochemical Cell having a Nanoslot, Application No. 13/508224.
For the most up-to-date list of publications, please click here:
- S. Basuray and H. -C. C”, hang, Induced dipoles and dielectrophoresis of nanocolloids in electrolytes. PRE, 75 (24897), 2007 DOI: 10.1103/PhysRevE.75.06050
- S. Basuray, S. Senapati, A. Aijan, A. Mahon and H. -C. Chang, Shear and AC Field Enhanced Carbon Nanotube Impedance Assay for Rapid, Sensitive, and Mismatch-Discriminating DNA Hybridization. ACS Nano, 3 (7), 2009 DOI: 10.1021/nn9004632
- X. Cheng, S. Basuray, S. Senapati and H. -C. Chang, Identification and separation of DNA-hybridized nanocolloids by Taylor cone harmonics, Electrophoresis, 30 (18), 2009 DOI: 10.1002/elps.200900159
- S. Basuray and H. -C. Chang, Designing a Sensitive and Quantifiable Nanocolloid Assay with Dielectrophoretic Cross-Over Frequencies. Biomicrofluidics, (Special Issue) 4, 013205, 2010 DOI: 10.1063/1.3294575
- I. F. Cheng, S. Senapati, X. Cheng, S. Basuray, H. -C. Chang and H. -C. Chang, A rapid field-use assay for mismatch number and location of hybridized DNA’s, Lab on a Chip, 10 (7), 2010 DOI: 10.1039/B925854J
- S. Basuray, H. H. Wei and H. -C. Chang, Dynamic Double-Layer Effects on AC-Induced Dipoles of Dielectric Nanocolloids. (Biomic rofluidics) (Special issue on Dielectrophoresis)(Leading Paper) 4, 022801, 2010 DOI: 10.1063/1.3455720
- S. Senapati, S. Basuray, Z. Slouka, L.-J. Cheng, and H.-C. Chang, A Nanomembrane-Based Nucleic Acid Sensing Platform for Portable Diagnostics, Top Curr. Chem., 304, 2011 DOI: 10.1007/128_2011_142
- S. C. Hamm, S. Basuray, S. Mukherjee, S. Sengupta, C. J. Mathai, G. A. Baker and S. Gangopadhyay, Ionic Conductivity Enhancement of Sputtered Gold Nanoparticle-in-Ionic Liquid Electrolytes, Journal of Material Chemistry A, 2013 DOI: 10.1039/C3TA13431H
- R. Thiruvengadathan, C. Stephen, S. Basuray, B. Balasubramanian, C. Staley, K. Gangopadhyay and S. Gangopadhyay, A Versatile and Controllable Self-Assembly Route Toward Nanoenergetic Composite with Tunable Combustion and Sensitivity Characteristics, Langmuir : the ACS journal of surfaces and colloids, 2014 DOI: 10.1021/la500573e
Invited Talks and Seminars
- “Label-free, Portable and Generic Diagnostic Device”, Food for the 21st Century, Department of Bioengineering, University of Missouri-Columbia, September, 2012.
- “Nano-Gap embedded Gratings for Surface Plasmon Enhanced Fluorescence”, Missouri Technology Expo, University of Missouri, September, 2013.