Sagnik Basuray, PhD, completed his doctoral studies from the University of Notre Dame in the department of Chemical and Bio-Molecular Engineering in 2011, where he won the best thesis award. Since 2012, he was working as a postdoctoral fellow in the department of Electrical and Computer Engineering, University of Missouri, at the Center for Micro/Nano Systems and Nanotechnology, in the area of materials science, nanotechnology and optics. Prior to his stint at Missouri, he was working as a Research Scientist at 454 Life Sciences, a Roche Company, building the next generation semi-conductor based sequencing platform.
At Notre Dame he worked extensively in nanofluidics, microfluidics with core competency in biomedical diagnostics to research interfacial electro-kinetic properties like dielectrophoresis. He designed robust, cost-effective Point-of-Care devices with electrochemical sensors as an alternative to real time PCR and DNA sensing. The sensor work has been licensed and developed by F Cubed LLC. and is now in clinical trials. His research was highlighted during the 2010 Michigan-Notre Dame football game at halftime as an ad to showcase the research activities at the University of Notre Dame. During his postdoctoral stint, he has developed top-down fabrication protocols (soft lithography) to fabricate hierarchical nano-ordered plasmonic/photonic structures which show extra-ordinary electro-magnetic field enhancement. These were used to investigate single biological molecules like DNA, RNA, FRET pairs and to develop multi spatial/temporal techniques (Raman, Fluorescence) from a single platform. Sagnik has always worked closely with groups from biochemistry, biology, biological engineering across many collaborative and interdisciplinary research projects.
Indian Institute of Technology (IIT), Bombay, India, B.Tech., 2002
University of Notre Dame, Indiana, US, PhD, 2011
2012-2014 – Post-doctoral research fellow, University of Missouri
2011-2012 – Research Scientist, 454 Life Sciences, a Roche company, Connecticut
Awards and Honors
2011 Eli J. and Helen Shaheen Graduate School Awards winner (award for top graduating doctoral degree recipient in the Graduate School of Engineering in the University of Notre Dame).
Fellowships for successive years 2006-2007, 2007-2008, from the Center for Applied Mathematics (CAM), University of Notre Dame, Indiana.
Our research efforts are to establish a synergy between novel nanostructures, optics (plasmonics and photonics), biology and electro-kinetics (microfluidics and nanofluidics) and integrate them to develop transformative and disruptive new technologies using cost-effective tools (3D printing). This will be instrumental in the development of fundamental understanding of interfaces and surface physics arising out of the interaction of metallic/dielectric atoms with biological molecules in an energy landscape.
We are developing a new, cost-effective soft lithographic technique adaptable to 3D printers for microfluidic and nanofluidic architecture. Successive iterations will introduce hierarchical nano-ordered plasmonic-photonic metallic/dielectric surface topology for optical/Raman enhancement across a broad wavelength spectrum.
Using the new surface DNA separation technique build upon surface entropic traps and electro-kinetic phenomena like dielectrophoresis (DEP), we will sequester, transport and thereby, isolate and/or concentrate species of interest. The goal is to fabricate a passive microfluidic MEMS device to isolate, concentrate and collect sweat for downstream measurement using the chromatographic surface DNA separation for measurement of Cystic Fibrosis.
We are envisioning a new class of devices with liquid-liquid interfaces instead of solid-liquid interface for next generation of modular sensors (for point-of-care diagnostics) that will use interfacial phenomenon, surface energy landscape, electro-kinetics, electro-magnetic field enhancement for identification and measurement of biological molecules of interest.
S. Gangopadhyay, V. Korampally, S. Basuray, K. Bhatnagar, A. Pathak, A. Ghosh, D. E. Menke, C. J. Mathai, P. V. Cornish, K. Gangopadhyay, “Nano-gap Grating Devices with Enhanced Optical Property and Fabrications thereof”, U.S Application No: 14/081353.
C. T. A. Wong, G. C. Ferreri, S. Basuray, A. Bappal, S. G. Shenoy, X. V. Gomes, “System and Method for Operation of ISFET Arrays using pH Insert Reference Sensors”, Application No: 13/970167
H. -C. Chang, J. Gordon, S. Senapati, Z. Gagnon and S. Basuray, Microfluidic Platforms for Multi-Target Detection, Application No: 12/246987 (Licensed to F Cube and receiving royalty payments since 2009).
P. Musenheim, S. Basuray, S. Senapati, G. Yossifon and H. –C. Chang, Microchamber Electrochemical Cell having a Nanoslot, Application No. 13/508224.
For the most up-to-date list of publications, please click here:
S. Basuray and H. -C. C”, hang, Induced dipoles and dielectrophoresis of nanocolloids in electrolytes. PRE, 75 (24897), 2007 DOI: 10.1103/PhysRevE.75.06050
S. Basuray, S. Senapati, A. Aijan, A. Mahon and H. -C. Chang, Shear and AC Field Enhanced Carbon Nanotube Impedance Assay for Rapid, Sensitive, and Mismatch-Discriminating DNA Hybridization. ACS Nano, 3 (7), 2009 DOI: 10.1021/nn9004632
X. Cheng, S. Basuray, S. Senapati and H. -C. Chang, Identification and separation of DNA-hybridized nanocolloids by Taylor cone harmonics, Electrophoresis, 30 (18), 2009 DOI: 10.1002/elps.200900159
S. Basuray and H. -C. Chang, Designing a Sensitive and Quantifiable Nanocolloid Assay with Dielectrophoretic Cross-Over Frequencies. Biomicrofluidics, (Special Issue) 4, 013205, 2010 DOI: 10.1063/1.3294575
I. F. Cheng, S. Senapati, X. Cheng, S. Basuray, H. -C. Chang and H. -C. Chang, A rapid field-use assay for mismatch number and location of hybridized DNA’s, Lab on a Chip, 10 (7), 2010 DOI: 10.1039/B925854J
S. Basuray, H. H. Wei and H. -C. Chang, Dynamic Double-Layer Effects on AC-Induced Dipoles of Dielectric Nanocolloids. (Biomic rofluidics) (Special issue on Dielectrophoresis)(Leading Paper) 4, 022801, 2010 DOI: 10.1063/1.3455720
S. Senapati, S. Basuray, Z. Slouka, L.-J. Cheng, and H.-C. Chang, A Nanomembrane-Based Nucleic Acid Sensing Platform for Portable Diagnostics, Top Curr. Chem., 304, 2011 DOI: 10.1007/128_2011_142
S. C. Hamm, S. Basuray, S. Mukherjee, S. Sengupta, C. J. Mathai, G. A. Baker and S. Gangopadhyay, Ionic Conductivity Enhancement of Sputtered Gold Nanoparticle-in-Ionic Liquid Electrolytes, Journal of Material Chemistry A, 2013 DOI: 10.1039/C3TA13431H
R. Thiruvengadathan, C. Stephen, S. Basuray, B. Balasubramanian, C. Staley, K. Gangopadhyay and S. Gangopadhyay, A Versatile and Controllable Self-Assembly Route Toward Nanoenergetic Composite with Tunable Combustion and Sensitivity Characteristics, Langmuir : the ACS journal of surfaces and colloids, 2014 DOI: 10.1021/la500573e
Invited Talks and Seminars
“Label-free, Portable and Generic Diagnostic Device”, Food for the 21st Century, Department of Bioengineering, University of Missouri-Columbia, September, 2012.
“Nano-Gap embedded Gratings for Surface Plasmon Enhanced Fluorescence”, Missouri Technology Expo, University of Missouri, September, 2013.